Gene Symbol | Rela |
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Entrez Gene | 19697 |
Alt Symbol | p65 |
Species | Mouse |
Gene Type | protein-coding |
Description | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
Other Description | avian reticuloendotheliosis viral (v-rel) oncogene homolog A|nuclear factor NF-kappa-B p65 subunit|nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|p65 NF kappaB|p65 NF-kappa B|p65 NFkB|transcription factor p65 |
Swissprots | Q62025 Q04207 |
Accessions | AAB00795 AAF82405 CAA80528 EDL33157 Q04207 AK089489 BAC40904 AK144565 AK154630 BAE32727 AK154938 AK155321 AK155889 BAE33485 AK157076 BAE33954 AK158072 BAE34348 AK181130 AK187191 AK191849 AK201334 AK202240 AK203832 AK208661 AK209267 AK210412 AK211432 AK212853 AK214156 AK215686 AK217652 BC003818 AAH03818 BC094053 AAH94053 DQ020177 AAY44745 EF460348 ABO60920 M61909 AAA39811 XM_006531694 XP_006531757 XM_006531695 XP_006531758 NM_009045 NP_033071 |
Function | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21131967}. Cytoplasm {ECO:0000269|PubMed:21131967}. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after lipopolysaccharide (LPS) stimulation. {ECO:0000250}. |
Top Pathways | Sphingolipid signaling pathway, Epstein-Barr virus infection, Legionellosis, Prolactin signaling pathway, Viral carcinogenesis |
RelA/NFkB p65 Antibody (2A12A7) - NBP1-45739 from Novus Biologicals
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NFkB p65 (phospho-Ser536) antibody - orb34981 from Biorbyt
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NFKP p65 antibody - 70R-34293 from Fitzgerald
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NFkB p65 antibody - 70R-37451 from Fitzgerald
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NFkB p65 antibody (Thr435) - 70R-37094 from Fitzgerald
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NFKP p100/p52 antibody (Ser869) - 70R-34298 from Fitzgerald
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NFKP p65 antibody (Ser468) - 70R-34308 from Fitzgerald
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NFKP p65 antibody - 70R-34313 from Fitzgerald
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NFkB p65 antibody (Ser281) - 70R-32610 from Fitzgerald
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NFkB p65 antibody (Thr254) - 70R-37092 from Fitzgerald
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NFkB p65 antibody (Ser529) - 70R-37284 from Fitzgerald
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NFKP p100/p52 antibody (Ser865) - 70R-34296 from Fitzgerald
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NFkB p65 antibody - 70R-37454 from Fitzgerald
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NFKP p65 antibody (Ser276) - 70R-34306 from Fitzgerald
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NFKP p65 antibody - 70R-34311 from Fitzgerald
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Synaptotagmin antibody (Ser309) - 70R-37277 from Fitzgerald
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NFkB p65 antibody (Thr505) - 70R-36798 from Fitzgerald
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NFKP p65 antibody (Ser311) - 70R-34294 from Fitzgerald
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NFkB p65 antibody - 70R-37452 from Fitzgerald
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NFkB p65 antibody (Ser468) - 70R-37095 from Fitzgerald
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NFKP p100/p52 antibody - 70R-34299 from Fitzgerald
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NFKP p65 antibody - 70R-34309 from Fitzgerald
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NFKP p65 antibody (Thr435) - 70R-34314 from Fitzgerald
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NFkB p65 antibody (Thr505) - 70R-37243 from Fitzgerald
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NFKP p65 antibody (Ser529) - 70R-34292 from Fitzgerald
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