Rela

Gene Symbol	Rela
Entrez Gene	19697
Alt Symbol	p65
Species	Mouse
Gene Type	protein-coding
Description	v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Other Description	avian reticuloendotheliosis viral (v-rel) oncogene homolog A|nuclear factor NF-kappa-B p65 subunit|nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|p65 NF kappaB|p65 NF-kappa B|p65 NFkB|transcription factor p65
Swissprots	Q62025 Q04207
Accessions	AAB00795 AAF82405 CAA80528 EDL33157 Q04207 AK089489 BAC40904 AK144565 AK154630 BAE32727 AK154938 AK155321 AK155889 BAE33485 AK157076 BAE33954 AK158072 BAE34348 AK181130 AK187191 AK191849 AK201334 AK202240 AK203832 AK208661 AK209267 AK210412 AK211432 AK212853 AK214156 AK215686 AK217652 BC003818 AAH03818 BC094053 AAH94053 DQ020177 AAY44745 EF460348 ABO60920 M61909 AAA39811 XM_006531694 XP_006531757 XM_006531695 XP_006531758 NM_009045 NP_033071
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location	Nucleus {ECO:0000269|PubMed:21131967}. Cytoplasm {ECO:0000269|PubMed:21131967}. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after lipopolysaccharide (LPS) stimulation. {ECO:0000250}.
Top Pathways	Sphingolipid signaling pathway, Epstein-Barr virus infection, Legionellosis, Prolactin signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® NF-κB p65 siRNA II (Mouse Specific) - 6339 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® NF-κB p65 siRNA I (Mouse Specific) - 6337 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

NFκB p65 siRNA (m) - sc-29411 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

NFκB p65 shRNA Plasmid (m) - sc-29411-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

NFκB p65 shRNA (m) Lentiviral Particles - sc-29411-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

NFκB p65 siRNA (m2) - sc-44213 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

NFκB p65 shRNA Plasmid (m2) - sc-44213-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

NFκB p65 shRNA (m2) Lentiviral Particles - sc-44213-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU076311 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN40072 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40072 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RELA siRNA (Mouse) - CRM3450 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

RELA - MBS8234822 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

Mouse RELA siRNA - orb282926 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

RELA shRNA Plasmid (Mouse) - CHM3450 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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