HLA-DQB2

Gene Symbol HLA-DQB2
Entrez Gene 3120
Alt Symbol HLA-DQB1, HLA-DXB
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class II, DQ beta 2
Other Description DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))|HLA class II histocompatibility antigen, DQ beta 2 chain|HLA class II histocompatibility antigen, DX beta chain|MHC class II antigen DQB2|major histocompatibility complex, class II, DQ beta 1
Swissprots Q29826 Q29873 Q29872 Q29871 Q5SR06 A6NIA5 Q29870 P05538
Accessions AAA52667 AAA52668 AAA52669 AAA52670 CAA60790 CAD20258 EAX03635 EAX03636 EAX03637 P05538 AK098007 BAG53563 BC031995 M95729 XM_005249051 XP_005249108 XM_005272807 XP_005272864 XM_005274855 XP_005274912 XM_005275546 XP_005275603 XM_011514560 XP_011512862 XM_011514561 XP_011512863 XM_011546309 XP_011544611 XM_011546310 XP_011544612 XM_011547242 XP_011545544 XM_011547243 XP_011545545 XM_011547646 XP_011545948 XM_011547647 XP_011545949 XM_011547648 XP_011545950 XM_011547877 XP_011546179 XM_011547878 XP_011546180 XM_011547879 XP_011546181 XM_011548045 XP_011546347 XM_011548046 XP_011546348 XM_011548047 XP_011546349 XM_011548233 XP_011546535 XM_011548234 XP_011546536 XM_011548235 XP_011546537 XM_011548425 XP_011546727 XM_011548426 XP_011546728 NM_001198858 NP_001185787 NM_182549 NR_003937 NM_001300790 NP_001287719
Function Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
Subcellular Location Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Tissue Specificity Restricted to skin Langerhans cells (at protein level). {ECO:0000269|PubMed:22407913}.

Anti-HLA-DQB2 antibody - ab126139 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HLA-DQB2 antibody (ab126139) at 1/1000 dilution + K562 lysate at 30 µg

Anti-HLA-DQB2 antibody - ab191511 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HLA-DQB2 antibody (ab191511)Lane 1 : HEK293T whole cell lysateLane 2 : MCF7 whole cell lysateLane 3 : Raw264.7 whole cell lysate

Anti-HLA-DQB2 antibody - ab76564 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-HLA-DQB2 antibody (ab76564) at 1/500 dilution + immunogen (GST-tagged recombinant full length protein) at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L) HRP-conjugated secondary antibody at 1/5000 dilution

Anti-HLA-DQB2 antibody - ab171923 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-HLA-DQB2 antibody (ab171923) at 1 µg/mlLane 1 : HLA-DQB2 transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H+L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-HLA-DQB1 Antibody - LS-C308260 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HLA-DQB1 Antibody - LS-C311223 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HLA-DQB1 Antibody (aa13-39) - LS-C203955 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HLA-DQB1 Antibody western blot of Daudi cell line lysates (35 ug/lane). The HLA-DQB1 antibody detected the HLA-DQB1 protein (arrow).

Anti-HLA-DQB1 Antibody (clone 4B7-E2) IHC-plus™ - LS-B6229 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4B7-E2
Anti-HLA-DQB1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6229 concentration 10 ug/ml.

Anti-HLA-DQB1 Antibody (clone Genox 3.53) - LS-C49047 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HLA-DQB2 Antibody - LS-C308261 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HLA-DQB2 Antibody - LS-C340982 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HLA-DQB2 Antibody - LS-C155234 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Colon ca, using HLA-DQB2 antibody at 1:500 dilution.

Anti-HLA-DQB2 Antibody (clone 4C3) - LS-C197417 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C3
Western Blot analysis of HLA-DQB2 expression in transfected 293T cell line by HLA-DQB2 monoclonal antibody (M01), clone 4C3.Lane 1: HLA-DQB2 transfected lysate (Predicted MW: 26.5 KDa).Lane 2: Non-transfected lysate.

HLA DQB1 Antibody - NBP1-84549 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HLA DQB1 Antibody [NBP1-84549] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

HLA DQB2 Antibody - NBP2-14984 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HLA DQB2 Antibody [NBP2-14984] - A: K562.

HLA DQB2 Antibody (4C3) - H00003120-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C3

HLA DQB2 Antibody - H00003120-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: HLA DQB2 Antibody [H00003120-B01P] - Analysis of HLA-DQB2 expression in transfected 293T cell line by HLA-DQB2 polyclonal antibody. Lane 1: HLA-DQB2 transfected lysate(26.50 KDa). Lane 2: Non-transfected lysate.

Anti-HLA-DQB2 antibody produced in mouse - SAB1401178 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-HLA-DQB2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401178</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~26.50 kDa using HLA-DQB2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Monoclonal Anti-HLA-DQB2 antibody produced in mouse - SAB1402224 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C3
<B>ELISA</B><BR/>Monoclonal Anti-HLA-DQB2, antibody produced in mouse, clone 4C3, purified immunoglobulin: <B>Cat. No. SAB1402224</B>: Detection limit for recombinant GST tagged HLA-DQB2 is approximately 1 ng/mL.

Anti-HLA-DQB2 antibody produced in rabbit - SAB2700851 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HLA-DQB2: <B>Cat. No. SAB2700851</B>: Immunohistochemical analysis of paraffin-embedded Colon ca, using HLA-DQB2 antibody at 1:250 dilution.

HLA-DQB1 Antibody (OALA05488) - OALA05488 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone [clone 4B7-E2]

HLA-DQB2 antibody - GTX104461 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-HLA-DQB2 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX104461
Search more