| Gene Symbol |
HLA-DQB2
|
| Entrez Gene |
3120
|
| Alt Symbol |
HLA-DQB1, HLA-DXB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
major histocompatibility complex, class II, DQ beta 2
|
| Other Description |
DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))|HLA class II histocompatibility antigen, DQ beta 2 chain|HLA class II histocompatibility antigen, DX beta chain|MHC class II antigen DQB2|major histocompatibility complex, class II, DQ beta 1
|
| Swissprots |
Q29826 Q29873 Q29872 Q29871 Q5SR06 A6NIA5 Q29870 P05538
|
| Accessions |
AAA52667 AAA52668 AAA52669 AAA52670 CAA60790 CAD20258 EAX03635 EAX03636 EAX03637 P05538 AK098007 BAG53563 BC031995 M95729 XM_005249051 XP_005249108 XM_005272807 XP_005272864 XM_005274855 XP_005274912 XM_005275546 XP_005275603 XM_011514560 XP_011512862 XM_011514561 XP_011512863 XM_011546309 XP_011544611 XM_011546310 XP_011544612 XM_011547242 XP_011545544 XM_011547243 XP_011545545 XM_011547646 XP_011545948 XM_011547647 XP_011545949 XM_011547648 XP_011545950 XM_011547877 XP_011546179 XM_011547878 XP_011546180 XM_011547879 XP_011546181 XM_011548045 XP_011546347 XM_011548046 XP_011546348 XM_011548047 XP_011546349 XM_011548233 XP_011546535 XM_011548234 XP_011546536 XM_011548235 XP_011546537 XM_011548425 XP_011546727 XM_011548426 XP_011546728 NM_001198858 NP_001185787 NM_182549 NR_003937 NM_001300790 NP_001287719
|
| Function |
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Endosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Lysosome membrane {ECO:0000269|PubMed:22407913}; Single-pass type I membrane protein {ECO:0000269|PubMed:22407913}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
|
| Tissue Specificity |
Restricted to skin Langerhans cells (at protein level). {ECO:0000269|PubMed:22407913}.
|
