Gene Symbol | MTHFR |
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Entrez Gene | 4524 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | methylenetetrahydrofolate reductase (NAD(P)H) |
Other Description | 5,10-methylenetetrahydrofolate reductase (NADPH)|methylenetetrahydrofolate reductase |
Swissprots | Q7Z6M6 Q9UQR2 B2R7A6 P42898 Q5SNW9 Q8IU73 Q5SNW6 |
Accessions | AAD17965 AAG33979 AAN40863 AAN40864 AAN40865 AAP88033 AAZ03741 ABB17330 ABK34493 CAB81551 CAB81552 EAW71708 EAW71709 P42898 AB209113 BAD92350 AJ237672 CAB41971 AK312907 BAG35753 AY046560 AAL17646 AY046561 AAL17647 AY046562 AAL17648 AY046563 AAL17649 AY046564 AAL17650 AY046565 AAL17651 BC011614 BC018766 BC053509 AAH53509 CN355286 JQ429447 AFQ62002 U09806 AAA74440 XM_005263458 XP_005263515 XM_005263460 XP_005263517 XM_005263461 XP_005263518 XM_005263462 XP_005263519 XM_005263463 XP_005263520 XM_011541495 XP_011539797 XM_011541496 XP_011539798 NM_005957 NP_005948 |
Function | Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. |
Top Pathways | Carbon metabolism, One carbon pool by folate |
MTHFR CRISPR/Cas9 KO Plasmid (h) - sc-406554 from Santa Cruz Biotechnology
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MTHFR HDR Plasmid (h) - sc-406554-HDR from Santa Cruz Biotechnology
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MTHFR Double Nickase Plasmid (h) - sc-406554-NIC from Santa Cruz Biotechnology
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MTHFR Double Nickase Plasmid (h2) - sc-406554-NIC-2 from Santa Cruz Biotechnology
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MTHFR CRISPR Activation Plasmid (h) - sc-406554-ACT from Santa Cruz Biotechnology
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MTHFR CRISPR Activation Plasmid (h2) - sc-406554-ACT-2 from Santa Cruz Biotechnology
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MTHFR Lentiviral Activation Particles (h) - sc-406554-LAC from Santa Cruz Biotechnology
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MTHFR Lentiviral Activation Particles (h2) - sc-406554-LAC-2 from Santa Cruz Biotechnology
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MTHFR siRNA (h) - sc-43950 from Santa Cruz Biotechnology
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MTHFR shRNA Plasmid (h) - sc-43950-SH from Santa Cruz Biotechnology
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MTHFR shRNA (h) Lentiviral Particles - sc-43950-V from Santa Cruz Biotechnology
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MTHFR RNAi - H00004524-R01 from Novus Biologicals
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MISSION® esiRNA - EHU028311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2315 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2315 from Sigma-Aldrich
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MTHFR siRNA (Human) - CRH3002 from Cohesion Biosciences
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MTHFR HDR Plasmid (h2) - sc-406554-HDR-2 from Santa Cruz Biotechnology
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MTHFR CRISPR/Cas9 KO Plasmid (h2) - sc-406554-KO-2 from Santa Cruz Biotechnology
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shRNA set against Human MTHFR (NM_005957.4) - SHH346352 from Creative biogene
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MTHFR shRNA Plasmid (Human) - CHH3002 from Cohesion Biosciences
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MTHFR miRNA 3'UTR clone - MiUTR4H-TG11780 from Creative biogene
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