TOP2B

Gene Symbol TOP2B
Entrez Gene 7155
Alt Symbol TOPIIB, top2beta
Species Human
Gene Type protein-coding
Description topoisomerase (DNA) II beta 180kDa
Other Description DNA topoisomerase 2-beta|DNA topoisomerase II beta|DNA topoisomerase II, 180 kD|DNA topoisomerase II, beta isozyme|U937 associated antigen|antigen MLAA-44|topo II beta|topoisomerase II beta|topoisomerase IIb
Swissprots Q9UMG8 Q9UQP8 Q02880 Q13600
Accessions AAB54121 AAB95437 CAA09753 CAA50726 CCQ43061 EAW64357 EAW64358 EAW64359 Q02880 AB208879 BAD92116 AK296510 BAG59142 AK297171 BAG59664 AK307450 AK316492 BAH14863 BC021863 AAH21863 BC054482 BC156330 AAI56331 BC157118 AAI57119 BF514624 BM150930 M27504 AAA61210 U54831 AAB01982 X53662 CAA37706 X68060 CAA48197 Z15111 CAA78815 Z15115 CAA78821 XM_005265427 XP_005265484 XM_011534057 XP_011532359 XR_940497 NM_001068 NP_001059
Function Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. {ECO:0000269|PubMed:10684600}.
Subcellular Location Cytoplasm. Nucleus, nucleolus.

Topo IIβ (C-12) - sc-48429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Topo IIb (C-12): sc-48429. Western blot analysis of Topo IIb expression in U-937 (A) and 3611-RF (B) nuclear extracts.

Topo IIβ (C-19) - sc-5352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Topo IIβ (C-19): sc-5352. Western blot analysis of Topo IIβ expression in HeLa (A) and K-562 (B) nuclear extracts.

Topo IIβ (F-19) - sc-5353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Topo IIβ (F-19): sc-5353. Western blot analysis of Topo IIβ expression in U-937 (A), MEG-01 (B), CCRF-CEM (C) and HeLa (D) nuclear extracts.

Topo IIβ (H-286) - sc-13059 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Topo IIβ (H-286): sc-13059. Western blot analysis of Topo IIβ expression in U-937 (A) and K-562 (B) nuclear extracts.

Topo IIβ (H-8) - sc-25330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Topo IIβ (H-8): sc-25330. Immunoperoxidase staining of formalin fixed, paraffin-embedded human parathyroid gland tissue showing nuclear staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-Topoisomerase II beta antibody - ab72334 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling Topoisomerase II beta with ab72334 at 1/200 (1µg/ml). Detection: DAB.

Anti-Topoisomerase II beta antibody - ab52769 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Topoisomerase II beta antibody (ab52769) at 1/1000 dilutionLane 1 : Total protein extract from E coli with ~50ng to 100 ng of an irrelevant antigenLane 2 : Total protein extract from E coli with ~50ng to 500ng of the antigen Lysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-Topoisomerase II beta antibody [EPR5377] - ab109524 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5377
ICC/IF image of ab109524 stained HeLa cells. The cells were 4% Formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab109524, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Topoisomerase II beta antibody [EPR5377] (Alexa Fluor® 647) - ab200993 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5377
ab200933 staining Topoisomerase II beta in HeLa cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200933 at 1/200 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Topoisomerase II beta antibody - ChIP Grade - ab58442 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Topoisomerase II beta antibody - ChIP Grade (ab58442) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : Jurkat cell extract with immunising peptide

Anti-TOP2B / Topoisomerase II Beta Antibody (aa1475-1525) - LS-C90620 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (C-Terminus) - LS-C90623 from LifeSpan Bioscience

Prices $530.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (aa1-50) - LS-C118622 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using TOP2B Antibody. The lane on the right is treated with the synthesized peptide.

Anti-TOP2B / Topoisomerase II Beta Antibody (aa1548-1597) - LS-C110235 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TOP2B antibody LS-C110235 Western blot of Jurkat lysate.

Anti-TOP2B / Topoisomerase II Beta Antibody (aa1439-1488) - LS-C109740 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TOP2B antibody LS-C109740 Western blot of Fetal Stomach lysate.

Anti-TOP2B / Topoisomerase II Beta Antibody - LS-C136868 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (C-Terminus) - LS-C137150 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (aa446-655, Biotin) - LS-C299481 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (aa446-655, FITC) - LS-C302977 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TOP2B / Topoisomerase II Beta Antibody (aa1475-1525) - LS-C287783 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Topo II Beta by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Topo II Beta used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-TOP2B / Topoisomerase II Beta Antibody (C-Terminus) - LS-C287782 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Topo II Beta by Immunohistochemistry. Sample: FFPE section of human small cell lung cancer. Antibody: Affinity purified rabbit anti-Topo II Beta used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

Anti-TOP2B / Topoisomerase II Beta Antibody (aa446-655) - LS-C296718 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TOP2B / Topoisomerase II Beta.

Anti-TOP2B / Topoisomerase II Beta Antibody (C-Terminus) - LS-C285926 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Topo II Beta by Immunohistochemistry. Sample: FFPE section of human ovarian cancer. Antibody: Affinity purified rabbit anti-Topo II Beta used at a dilution of 1:250.

Anti-TOP2B / Topoisomerase II Beta Antibody - LS-C335382 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HepG2 cell line, using TOP2B antibody.

Anti-TOP2B / Topoisomerase II Beta Antibody (Internal, clone EPR5377) - LS-C138511 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5377
IHC of paraffin-embedded human breast tissue using anti-Topoisomerase II Beta antibody.
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