| Gene Symbol |
TGM3
|
| Entrez Gene |
7053
|
| Alt Symbol |
TGE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transglutaminase 3
|
| Other Description |
E polypeptide, protein-glutamine-gamma-glutamyltransferase|TG(E)|TGase E|TGase-3|protein-glutamine gamma-glutamyltransferase E|transglutaminase E|transglutaminase-3
|
| Swissprots |
A8K5N6 Q08188 O95933 Q32MM0 Q32ML9 D3DVX1 B2RCR6
|
| Accessions |
AAD14962 ABK41960 CCQ43210 EAX10601 EAX10602 Q08188 AI216028 AK290324 BAF83013 AK291351 BAF84040 AK298637 BAG60812 AK299447 BAG61420 AK308249 AK315236 BAG37663 AL602787 AL691671 AW265475 BC109075 AAI09076 BC109076 AAI09077 BG675531 BX284087 DC373633 L10386 AAA61155 N23065 NM_003245 NP_003236
|
| Function |
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. {ECO:0000250}.
|