Gene Symbol | TGM3 |
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Entrez Gene | 7053 |
Alt Symbol | TGE |
Species | Human |
Gene Type | protein-coding |
Description | transglutaminase 3 |
Other Description | E polypeptide, protein-glutamine-gamma-glutamyltransferase|TG(E)|TGase E|TGase-3|protein-glutamine gamma-glutamyltransferase E|transglutaminase E|transglutaminase-3 |
Swissprots | A8K5N6 Q08188 O95933 Q32MM0 Q32ML9 D3DVX1 B2RCR6 |
Accessions | AAD14962 ABK41960 CCQ43210 EAX10601 EAX10602 Q08188 AI216028 AK290324 BAF83013 AK291351 BAF84040 AK298637 BAG60812 AK299447 BAG61420 AK308249 AK315236 BAG37663 AL602787 AL691671 AW265475 BC109075 AAI09076 BC109076 AAI09077 BG675531 BX284087 DC373633 L10386 AAA61155 N23065 NM_003245 NP_003236 |
Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. {ECO:0000250}. |
TGase3 CRISPR/Cas9 KO Plasmid (h) - sc-406800 from Santa Cruz Biotechnology
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TGase3 HDR Plasmid (h) - sc-406800-HDR from Santa Cruz Biotechnology
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TGase3 Double Nickase Plasmid (h) - sc-406800-NIC from Santa Cruz Biotechnology
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TGase3 Double Nickase Plasmid (h2) - sc-406800-NIC-2 from Santa Cruz Biotechnology
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TGase3 CRISPR Activation Plasmid (h) - sc-406800-ACT from Santa Cruz Biotechnology
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TGase3 CRISPR Activation Plasmid (h2) - sc-406800-ACT-2 from Santa Cruz Biotechnology
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TGase3 Lentiviral Activation Particles (h) - sc-406800-LAC from Santa Cruz Biotechnology
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TGase3 Lentiviral Activation Particles (h2) - sc-406800-LAC-2 from Santa Cruz Biotechnology
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TGase3 siRNA (h) - sc-37516 from Santa Cruz Biotechnology
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TGase3 shRNA Plasmid (h) - sc-37516-SH from Santa Cruz Biotechnology
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TGase3 shRNA (h) Lentiviral Particles - sc-37516-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU139271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21283 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21283 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04332 from Sigma-Aldrich
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TGM3 siRNA (Human) - CRH4826 from Cohesion Biosciences
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Transglutaminase 3/TGM3 RNAi - H00007053-R01 from Novus Biologicals
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TGM3 - MBS8201442 from MyBioSource
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shRNA set against Human TGM3 (NM_003245.3) - SHH426544 from Creative biogene
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TGase3 CRISPR/Cas9 KO Plasmid (h2) - sc-406800-KO-2 from Santa Cruz Biotechnology
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TGase3 HDR Plasmid (h2) - sc-406800-HDR-2 from Santa Cruz Biotechnology
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Human TGM3 siRNA - orb265328 from Biorbyt
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TGM3 shRNA Plasmid (Human) - CHH4826 from Cohesion Biosciences
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TGM3 miRNA 3'UTR clone - MiUTR4H-TG08932 from Creative biogene
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