| Gene Symbol |
CEP72
|
| Entrez Gene |
55722
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centrosomal protein 72kDa
|
| Other Description |
centrosomal protein of 72 kDa
|
| Swissprots |
B4DR26 Q9BWM3 Q9BV03 Q9NVR4 Q9P209
|
| Accessions |
EAW51011 EAW51012 EAW51013 Q9P209 AB040952 BAA96043 AK001427 BAA91685 AK299072 BAG61138 BC000132 AAH00132 BC001750 AAH01750 BG718176 XM_005248322 XP_005248379 XM_005248323 XP_005248380 XM_011514063 XP_011512365 XM_011514064 XP_011512366 XM_011514065 XP_011512367 XM_011514066 XP_011512368 XR_925628 XR_925630 XR_925631 NM_018140 NP_060610
|
| Function |
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). {ECO:0000269|PubMed:19536135}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19536135}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
|
![Western Blot: CEP72 Overexpression Lysate (Adult Normal) [NBL1-09105] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CEP72.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6063_CEP72%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09105-img0002.jpg)