Gene Symbol | CEP72 |
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Entrez Gene | 55722 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | centrosomal protein 72kDa |
Other Description | centrosomal protein of 72 kDa |
Swissprots | B4DR26 Q9BWM3 Q9BV03 Q9NVR4 Q9P209 |
Accessions | EAW51011 EAW51012 EAW51013 Q9P209 AB040952 BAA96043 AK001427 BAA91685 AK299072 BAG61138 BC000132 AAH00132 BC001750 AAH01750 BG718176 XM_005248322 XP_005248379 XM_005248323 XP_005248380 XM_011514063 XP_011512365 XM_011514064 XP_011512366 XM_011514065 XP_011512367 XM_011514066 XP_011512368 XR_925628 XR_925630 XR_925631 NM_018140 NP_060610 |
Function | Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). {ECO:0000269|PubMed:19536135}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19536135}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner. |
CEP72 CRISPR/Cas9 KO Plasmid (h) - sc-412583 from Santa Cruz Biotechnology
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CEP72 HDR Plasmid (h) - sc-412583-HDR from Santa Cruz Biotechnology
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CEP72 Double Nickase Plasmid (h) - sc-412583-NIC from Santa Cruz Biotechnology
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CEP72 Double Nickase Plasmid (h2) - sc-412583-NIC-2 from Santa Cruz Biotechnology
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CEP72 CRISPR Activation Plasmid (h) - sc-412583-ACT from Santa Cruz Biotechnology
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CEP72 CRISPR Activation Plasmid (h2) - sc-412583-ACT-2 from Santa Cruz Biotechnology
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CEP72 Lentiviral Activation Particles (h) - sc-412583-LAC from Santa Cruz Biotechnology
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CEP72 Lentiviral Activation Particles (h2) - sc-412583-LAC-2 from Santa Cruz Biotechnology
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CEP72 siRNA (h) - sc-92072 from Santa Cruz Biotechnology
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CEP72 shRNA Plasmid (h) - sc-92072-SH from Santa Cruz Biotechnology
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CEP72 shRNA (h) Lentiviral Particles - sc-92072-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU041081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5974 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5974 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04732 from Sigma-Aldrich
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CEP72 siRNA (Human) - CRJ0863 from Cohesion Biosciences
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CEP72 - MBS8224963 from MyBioSource
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shRNA set against Human CEP72 (NM_018140.3) - SHH261997 from Creative biogene
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Human CEP72 siRNA - orb271364 from Biorbyt
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CEP72 shRNA Plasmid (Human) - CHJ0863 from Cohesion Biosciences
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CEP72 miRNA 3'UTR clone - MiUTR1H-02059 from Creative biogene
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