ARHGAP21
| Gene Symbol | ARHGAP21 |
|---|---|
| Entrez Gene | 57584 |
| Alt Symbol | ARHGAP10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho GTPase activating protein 21 |
| Other Description | Rho-GTPase activating protein 10|rho GTPase-activating protein 10|rho GTPase-activating protein 21|rho-type GTPase-activating protein 21 |
| Swissprots | Q7Z3P7 Q9P2C3 Q8TBV5 Q5T5U3 Q8NI19 Q8N3A2 Q0VF98 |
| Accessions | EAW86122 Q5T5U3 AB037845 BAA92662 AF480466 AAM22955 AK074589 AK090642 AK295649 BAH12139 AK297278 BAG59749 AK307604 AL834495 CAD39153 AV709499 AV709848 BC022931 AAH22931 BC118915 AAI18916 BI491305 BQ026288 BX537570 CAD97787 XM_005252542 XP_005252599 XM_005252544 XP_005252601 XM_011519602 XP_011517904 XM_011519603 XP_011517905 XM_011519604 XP_011517906 XM_011519605 XP_011517907 XM_011519606 XP_011517908 XM_011519607 XP_011517909 XR_242701 XR_930513 NM_020824 NP_065875 |
| Function | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
| Subcellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. |
| Tissue Specificity | Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269|PubMed:12056806}. |
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![Immunohistochemistry: ARHGAP21 Antibody [NBP1-90852] - Staining of human gall bladder shows distinct nuclear and cytoplasmic positivity in glandular cells.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_4/25717_ARHGAP21-Antibody-Immunohistochemistry-NBP1-90852-img0003.jpg)
