Gene Symbol | ARHGAP21 |
---|---|
Entrez Gene | 57584 |
Alt Symbol | ARHGAP10 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 21 |
Other Description | Rho-GTPase activating protein 10|rho GTPase-activating protein 10|rho GTPase-activating protein 21|rho-type GTPase-activating protein 21 |
Swissprots | Q7Z3P7 Q9P2C3 Q8TBV5 Q5T5U3 Q8NI19 Q8N3A2 Q0VF98 |
Accessions | EAW86122 Q5T5U3 AB037845 BAA92662 AF480466 AAM22955 AK074589 AK090642 AK295649 BAH12139 AK297278 BAG59749 AK307604 AL834495 CAD39153 AV709499 AV709848 BC022931 AAH22931 BC118915 AAI18916 BI491305 BQ026288 BX537570 CAD97787 XM_005252542 XP_005252599 XM_005252544 XP_005252601 XM_011519602 XP_011517904 XM_011519603 XP_011517905 XM_011519604 XP_011517906 XM_011519605 XP_011517907 XM_011519606 XP_011517908 XM_011519607 XP_011517909 XR_242701 XR_930513 NM_020824 NP_065875 |
Function | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}. |
Subcellular Location | Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. |
Tissue Specificity | Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269|PubMed:12056806}. |
ARHGAP21 CRISPR/Cas9 KO Plasmid (h) - sc-403424 from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 HDR Plasmid (h) - sc-403424-HDR from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 Double Nickase Plasmid (h) - sc-403424-NIC from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 Double Nickase Plasmid (h2) - sc-403424-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 CRISPR Activation Plasmid (h) - sc-403424-ACT from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 CRISPR Activation Plasmid (h2) - sc-403424-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 Lentiviral Activation Particles (h) - sc-403424-LAC from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 Lentiviral Activation Particles (h2) - sc-403424-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 siRNA (h) - sc-90334 from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 shRNA Plasmid (h) - sc-90334-SH from Santa Cruz Biotechnology
|
||||||||
ARHGAP21 shRNA (h) Lentiviral Particles - sc-90334-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU042911 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3415 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3415 from Sigma-Aldrich
|
||||||||
ARHGAP21 siRNA (Human) - CRJ1558 from Cohesion Biosciences
|
||||||||
ARHGAP21 - MBS8200143 from MyBioSource
|
||||||||
shRNA set against Human ARHGAP21 (NM_020824.3) - SHH239386 from Creative biogene
|
||||||||
Human ARHGAP21 siRNA - orb272059 from Biorbyt
|
||||||||
ARHGAP21 shRNA Plasmid (Human) - CHJ1558 from Cohesion Biosciences
|
||||||||
ARHGAP21 miRNA 3'UTR clone - MiUTR3H-10864 from Creative biogene
|