| Gene Symbol |
CNIH3
|
| Entrez Gene |
149111
|
| Alt Symbol |
CNIH-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cornichon family AMPA receptor auxiliary protein 3
|
| Other Description |
cornichon homolog 3|protein cornichon homolog 3
|
| Swissprots |
Q8TBE1
|
| Accessions |
EAW69732 Q8TBE1 AF070524 AK096312 BAC04760 BC022780 AAH22780 HQ447327 ADQ31813 XM_005273075 XP_005273132 XM_011544101 XP_011542403 XM_011544102 XP_011542404 XM_011544103 XP_011542405 XM_011544104 XP_011542406 XM_011544105 XP_011542407 XM_011544106 XP_011542408 XM_011544107 XP_011542409 NM_152495 NP_689708
|
| Function |
Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. {ECO:0000269|PubMed:20805473}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). {ECO:0000250}.
|
| Tissue Specificity |
Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study). {ECO:0000269|PubMed:23103966}.
|
![Western Blot: CNIH3 Overexpression Lysate (Adult Normal) [NBL1-09311] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNIH3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3012_CNIH3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09311-img0002.jpg)