| Gene Symbol |
CRADD
|
| Entrez Gene |
8738
|
| Alt Symbol |
MRT34, RAIDD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CASP2 and RIPK1 domain containing adaptor with death domain
|
| Other Description |
RIP-associated ICH1/CED3-homologous protein with death domain|RIP-associated protein with a death domain|caspase and RIP adaptor with death domain|death adaptor molecule RAIDD|death domain-containing protein CRADD
|
| Swissprots |
B7Z2Q5 P78560
|
| Accessions |
EAW97497 P78560 AA150833 AB451280 BAG70094 AB451412 BAG70226 AI791547 AK294986 BAH11941 AK296225 BAG58948 AK314861 BAG37377 BC017042 AAH17042 BC037905 AAH37905 BT009837 AAP88839 CD696130 CR407643 CAG28571 DQ891780 ABM82706 DQ894964 ABM85890 U79115 AAB42217 U84388 AAC50952 XM_005269211 XP_005269268 NM_003805 NP_003796
|
| Function |
Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
|