Gene Symbol | PKN3 |
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Entrez Gene | 29941 |
Alt Symbol | UTDP4-1 |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase N3 |
Other Description | protein kinase PKN-beta|protein-kinase C-related kinase 3|serine/threonine-protein kinase N3 |
Swissprots | Q6P5Z2 Q9UM03 |
Accessions | EAW87824 EAW87825 Q6P5Z2 AB019692 BAA85625 AI741632 AK097535 BC023327 BC032794 AAH32794 BC041581 BC062558 AAH62558 BQ009753 BU854923 CB987960 EU831416 ACE87103 EU831509 ACE86428 XM_005251946 XP_005252003 XM_006717080 XP_006717143 XM_006717082 XP_006717145 XM_011518595 XP_011516897 XM_011518596 XP_011516898 XM_011518597 XP_011516899 XM_011518598 XP_011516900 NM_013355 NP_037487 |
Function | Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10441506}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10441506}. Note=Nuclear and perinuclear Golgi region. |
Tissue Specificity | Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues. {ECO:0000269|PubMed:10441506}. |
Top Pathways | Salmonella infection, PI3K-Akt signaling pathway |
PKNβ siRNA (h) - sc-62822 from Santa Cruz Biotechnology
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PKNβ shRNA Plasmid (h) - sc-62822-SH from Santa Cruz Biotechnology
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PKNβ shRNA (h) Lentiviral Particles - sc-62822-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU009671 from Sigma-Aldrich
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MISSION® siRNA - SIHK1739 from Sigma-Aldrich
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MISSION® siRNA - SIHK1738 from Sigma-Aldrich
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MISSION® siRNA - SIHK1740 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16873 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03358 from Sigma-Aldrich
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PKN3 siRNA (Human) - CRH9283 from Cohesion Biosciences
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PKN3 RNAi - H00029941-R02 from Novus Biologicals
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shRNA set against Human Pkn3 (NM_013355.3) - SHH376564 from Creative biogene
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shRNA set against Human PKN3(NM_013355.3) - SHR118144 from Creative biogene
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Human PKN3 siRNA - orb269785 from Biorbyt
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PKN3 shRNA Plasmid (Human) - CHH9283 from Cohesion Biosciences
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PKN3 miRNA 3'UTR clone - MiUTR1H-07945 from Creative biogene
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