| Gene Symbol |
FEV
|
| Entrez Gene |
54738
|
| Alt Symbol |
HSRNAFEV, PET-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FEV (ETS oncogene family)
|
| Other Description |
PC12 ETS domain-containing transcription factor 1|fifth Ewing variant protein|protein FEV
|
| Swissprots |
Q99581
|
| Accessions |
AAX88917 EAW70664 Q99581 BC023511 AAH23511 DQ893402 ABM84328 DQ896784 ABM87783 Y08976 CAA70169 NM_017521 NP_059991
|
| Function |
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:12761502}.
|
| Tissue Specificity |
In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine. {ECO:0000269|PubMed:15003288, ECO:0000269|PubMed:15986391, ECO:0000269|PubMed:9121764}.
|
| Top Pathways |
Transcriptional misregulation in cancer
|