Gene Symbol | FEV |
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Entrez Gene | 54738 |
Alt Symbol | HSRNAFEV, PET-1 |
Species | Human |
Gene Type | protein-coding |
Description | FEV (ETS oncogene family) |
Other Description | PC12 ETS domain-containing transcription factor 1|fifth Ewing variant protein|protein FEV |
Swissprots | Q99581 |
Accessions | AAX88917 EAW70664 Q99581 BC023511 AAH23511 DQ893402 ABM84328 DQ896784 ABM87783 Y08976 CAA70169 NM_017521 NP_059991 |
Function | Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. {ECO:0000269|PubMed:12761502}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237, ECO:0000269|PubMed:12761502}. |
Tissue Specificity | In brain, exclusively expressed in the major serotonergic neurons of the dorsal and median raphe nuclei located in the midbrain and pons. Also detected in prostate and small intestine. {ECO:0000269|PubMed:15003288, ECO:0000269|PubMed:15986391, ECO:0000269|PubMed:9121764}. |
Top Pathways | Transcriptional misregulation in cancer |
FEV CRISPR/Cas9 KO Plasmid (h) - sc-405201 from Santa Cruz Biotechnology
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FEV HDR Plasmid (h) - sc-405201-HDR from Santa Cruz Biotechnology
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FEV Double Nickase Plasmid (h) - sc-405201-NIC from Santa Cruz Biotechnology
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FEV Double Nickase Plasmid (h2) - sc-405201-NIC-2 from Santa Cruz Biotechnology
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FEV CRISPR Activation Plasmid (h) - sc-405201-ACT from Santa Cruz Biotechnology
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FEV CRISPR Activation Plasmid (h2) - sc-405201-ACT-2 from Santa Cruz Biotechnology
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FEV Lentiviral Activation Particles (h) - sc-405201-LAC from Santa Cruz Biotechnology
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FEV Lentiviral Activation Particles (h2) - sc-405201-LAC-2 from Santa Cruz Biotechnology
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FEV siRNA (h) - sc-37859 from Santa Cruz Biotechnology
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FEV shRNA Plasmid (h) - sc-37859-SH from Santa Cruz Biotechnology
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FEV shRNA (h) Lentiviral Particles - sc-37859-V from Santa Cruz Biotechnology
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Pet1 RNAi - H00054738-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8630 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8630 from Sigma-Aldrich
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FEV siRNA (Human) - CRJ0190 from Cohesion Biosciences
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FEV - MBS8235080 from MyBioSource
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shRNA set against Human FEV (NM_017521.2) - SHH294169 from Creative biogene
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shRNA set against Human FEV(NM_017521.2) - SHH055901 from Creative biogene
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Human FEV siRNA - orb270691 from Biorbyt
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FEV shRNA Plasmid (Human) - CHJ0190 from Cohesion Biosciences
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FEV miRNA 3'UTR clone - MiUTR1H-03614 from Creative biogene
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