KLK3

Gene Symbol KLK3
Entrez Gene 354
Alt Symbol APS, KLK2A1, PSA, hK3
Species Human
Gene Type protein-coding
Description kallikrein-related peptidase 3
Other Description P-30 antigen|gamma-seminoprotein|kallikrein-3|prostate specific antigen|prostate-specific antigen|semenogelase|seminin
Swissprots P07288 Q8IXI4 Q16272 G3XAE3 Q86TG8 C9JXH3 Q15096 G3V0H4
Accessions AAA60192 AAA60193 AAG33355 CAA32123 CAA32124 CAA32126 CAA32127 CAA32915 CAB46487 EAW71922 EAW71923 EAW71924 EAW71925 EAW71926 EAW71927 EAW71928 EAW71929 EAW71930 EAW71931 EAW71932 EAW71933 EAW71934 EAW71935 EAW71936 P07288 AF335477 AAL73204 AF335478 AAL73205 AJ310937 CAC41631 AJ310938 CAC41632 AJ459782 CAD30844 AJ459783 CAD30845 AJ459784 CAD30846 AJ512346 CAD54617 AK312933 BAG35776 AX772834 CAE06266 BC005307 AAH05307 BC050595 AAH50595 BC056665 AAH56665 BF679511 BQ932072 BT019862 AAV38665 DQ641251 DQ890670 ABM81596 DQ893851 ABM84777 M21895 AAA59995 M21896 AAA59996 M21897 AAA59997 M26663 AAA58802 S75755 AAD14185 U17040 AAA56764 X05332 CAA28947 X07730 X75682 XM_011526923 XP_011525225 XM_011526924 XP_011525226 XR_935817 NM_001030047 NP_001025218 NM_001030048 NP_001025219 NM_001648 NP_001639 NM_001030049 NM_001030050
Function Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Subcellular Location Secreted.
Top Pathways Prostate cancer

PSA/KLK3 (D6B1) XP ® Rabbit mAb - 5365 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6B1
Western blot analysis of extracts from LNCaP (PSA positive) and DU 145 (PSA negative) cells using PSA/KLK3 (D6B1) XP ® Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

PSA/KLK3 (D11E1) XP ® Rabbit mAb - 2475 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11E1
Western blot analysis of extracts from human sperm and LNCaP and DU 145 cells using PSA/KLK3 (D11E1) XP ® Rabbit mAb. DU 145 cells are negative as expected.

PSA/KLK3 (D2A8) Rabbit mAb - 5877 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2A8
Western blot analysis of extracts from LNCaP (PSA positive) and DU 145 (PSA negative) cells using PSA/KLK3 (D2A8) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

PSA/ACT (2F5) - sc-53143 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

PSA/ACT (4G10) - sc-53144 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSA/ACT (4G10): sc-53144. Western blot analysis of PSA/ACT expression in PC-3 whole cell lysate.

PSA (A67-B/E3) - sc-7316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PSA (A67-B/E3): sc-7316. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate tissue cytoplasmic staining.

PSA (C-19) - sc-7638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PSA (C-19): sc-7638. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tumor showing cytoplasmic localization.

PSA (SPM352) - sc-65602 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl ascites
Host Mouse
Clonality Monoclonal
PSA (SPM352): sc-65602. Western blot analysis of PSA expression in LNCaP whole cell lysate.

Anti-Prostate Specific Antigen antibody - ab9537 from Abcam

Prices $382.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human prostate carcinoma tissue, staining Prostate Specific Antigen with ab9537. Staining was detected using DAB.

Anti-Prostate Specific Antigen antibody - ab53774 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Prostate Specific Antigen antibody (ab53774) at 1/500 dilutionLane 1 : Extracts from mouse heartLane 2 : Extracts from mouse heart, plus immunising peptide

Anti-Prostate Specific Antigen antibody - ab115960 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab60123 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Prostate Specific Antigen antibody (ab60123) at 1/100 dilution + mouse brain tissue lysate

Anti-Prostate Specific Antigen antibody - ab75684 from Abcam

Prices $376.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab75684, at 1/200 dilution, staining Prostate Specific Antigen in Human prostate by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-Prostate Specific Antigen antibody - ab111858 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Prostate Specific Antigen antibody (ab111858) at 1 µg/mlLane 1 : Prostate (Human) Whole Cell Lysate - liver cirrhosis (ab30307)Lane 2 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Prostate Specific Antigen antibody - ab35355 from Abcam

Prices $372.00
Sizes 500 µl
Host Sheep
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab47783 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab19554 from Abcam

Prices $370.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab33609 from Abcam

Prices $370.00
Sizes 250 µg
Host Goat
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab33630 from Abcam

Prices $370.00
Sizes 500 µg
Host Chicken
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab93668 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Prostate Specific Antigen antibody - ab46976 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Prostate Specific Antigen antibody (ab46976) at 1/1000 dilution + LNCaP cells

Anti-Prostate Specific Antigen antibody [1H12] - ab130880 from Abcam

Prices $370.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 1H12

Anti-Prostate Specific Antigen antibody [2H9] - ab10184 from Abcam

Prices $376.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 2H9
ICC/IF image of ab10184 stained PC3 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab10184, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Prostate Specific Antigen antibody [35H9], prediluted - ab188119 from Abcam

Prices $376.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone 35H9
Immunohistochemical analysis of paraffine embedded human prostate labeling Prostate Specific Antigen using ab188119.

Anti-Prostate Specific Antigen antibody [3E6] - ab140337 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E6
Immunofluorescent analysis of Human LNCaP cells labelling Prostate Specific Antigen (PSA) with ab140337 at dilution 1/100.
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