Gene Symbol | SMDT1 |
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Entrez Gene | 91689 |
Alt Symbol | C22orf32, DDDD, EMRE, dJ186O1.1 |
Species | Human |
Gene Type | protein-coding |
Description | single-pass membrane protein with aspartate-rich tail 1 |
Other Description | UPF0466 protein C22orf32, mitochondrial|essential MCU regulator, mitochondrial|single-pass membrane protein with aspartate-rich tail 1, mitochondrial |
Swissprots | Q9H4I9 Q8TAB9 B2R5D1 |
Accessions | EAW60488 Q9H4I9 AK095636 AK312142 BAG35078 AL449243 CAC15000 BC024237 AAH24237 BI754670 CR456453 CAG30339 XM_011530509 XP_011528811 XM_011547037 XP_011545339 XM_011547542 XP_011545844 XM_011547754 XP_011546056 NM_033318 NP_201575 |
Function | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium- sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. {ECO:0000269|PubMed:24231807}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:24231807}; Single-pass membrane protein {ECO:0000269|PubMed:24231807}. |
C22orf32 CRISPR/Cas9 KO Plasmid (h) - sc-402149 from Santa Cruz Biotechnology
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C22orf32 HDR Plasmid (h) - sc-402149-HDR from Santa Cruz Biotechnology
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C22orf32 Double Nickase Plasmid (h) - sc-402149-NIC from Santa Cruz Biotechnology
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C22orf32 Double Nickase Plasmid (h2) - sc-402149-NIC-2 from Santa Cruz Biotechnology
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C22orf32 CRISPR Activation Plasmid (h) - sc-402149-ACT from Santa Cruz Biotechnology
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C22orf32 CRISPR Activation Plasmid (h2) - sc-402149-ACT-2 from Santa Cruz Biotechnology
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C22orf32 Lentiviral Activation Particles (h) - sc-402149-LAC from Santa Cruz Biotechnology
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C22orf32 Lentiviral Activation Particles (h2) - sc-402149-LAC-2 from Santa Cruz Biotechnology
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C22orf32 siRNA (h) - sc-72762 from Santa Cruz Biotechnology
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C22orf32 shRNA Plasmid (h) - sc-72762-SH from Santa Cruz Biotechnology
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C22orf32 shRNA (h) Lentiviral Particles - sc-72762-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4795 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08510 from Sigma-Aldrich
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SMDT1 siRNA (Human) - CRJ4068 from Cohesion Biosciences
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SMDT1 - MBS8213528 from MyBioSource
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shRNA set against Human C22orf32 (NM_033318.4) - SHH251249 from Creative biogene
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Human SMDT1 siRNA - orb274569 from Biorbyt
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SMDT1 shRNA Plasmid (Human) - CHJ4068 from Cohesion Biosciences
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C22ORF32 miRNA 3'UTR clone - MiUTR3H-13755 from Creative biogene
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