| Gene Symbol |
PPIL2
|
| Entrez Gene |
23759
|
| Alt Symbol |
CYC4, CYP60, Cyp-60, UBOX7, hCyP-60
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl isomerase (cyclophilin)-like 2
|
| Other Description |
PPIase|U-box domain containing 7|cyclophilin, 60kDa|cyclophilin-60|cyclophilin-like protein CyP-60|peptidyl-prolyl cis-trans isomerase-like 2|peptidylprolyl cis-trans isomerase|rotamase PPIL2
|
| Swissprots |
Q13356 Q8TAH2 Q13357 Q9BWR8
|
| Accessions |
EAW59469 EAW59470 EAW59471 EAW59472 EAW59473 EAW59474 EAW59475 EAW59476 Q13356 AA743164 AF320072 AAK07635 AK097249 AK127259 AK289545 BAF82234 AK299206 BAG61246 AL702046 BC000022 AAH00022 BC028385 AAH28385 BM981665 CR456548 CAG30434 CU013148 CAK54579 CU013436 CAK54878 DA863607 DQ891659 ABM82585 DQ894846 ABM85772 U37219 AAC50376 U37220 AAC50377 U37221 AAC50378 XM_005261447 XP_005261504 XM_005261448 XP_005261505 XM_011530041 XP_011528343 XM_011530042 XP_011528344 XM_011530043 XP_011528345 XM_011530044 XP_011528346 XM_011530045 XP_011528347 XM_011530046 XP_011528348 XM_011530047 XP_011528349 XM_011530048 XP_011528350 XM_011530049 XP_011528351 XM_011530050 XP_011528352 XM_011530051 XP_011528353 NM_014337 NP_055152 NM_148175 NP_680480 NM_148176 NP_680481
|
| Function |
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). {ECO:0000250|UniProtKB:Q08752, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000303|PubMed:8660300}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269|PubMed:15946952}.
|
| Tissue Specificity |
Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas. {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|