PPIL2

Gene Symbol	PPIL2
Entrez Gene	23759
Alt Symbol	CYC4, CYP60, Cyp-60, UBOX7, hCyP-60
Species	Human
Gene Type	protein-coding
Description	peptidylprolyl isomerase (cyclophilin)-like 2
Other Description	PPIase|U-box domain containing 7|cyclophilin, 60kDa|cyclophilin-60|cyclophilin-like protein CyP-60|peptidyl-prolyl cis-trans isomerase-like 2|peptidylprolyl cis-trans isomerase|rotamase PPIL2
Swissprots	Q13356 Q8TAH2 Q13357 Q9BWR8
Accessions	EAW59469 EAW59470 EAW59471 EAW59472 EAW59473 EAW59474 EAW59475 EAW59476 Q13356 AA743164 AF320072 AAK07635 AK097249 AK127259 AK289545 BAF82234 AK299206 BAG61246 AL702046 BC000022 AAH00022 BC028385 AAH28385 BM981665 CR456548 CAG30434 CU013148 CAK54579 CU013436 CAK54878 DA863607 DQ891659 ABM82585 DQ894846 ABM85772 U37219 AAC50376 U37220 AAC50377 U37221 AAC50378 XM_005261447 XP_005261504 XM_005261448 XP_005261505 XM_011530041 XP_011528343 XM_011530042 XP_011528344 XM_011530043 XP_011528345 XM_011530044 XP_011528346 XM_011530045 XP_011528347 XM_011530046 XP_011528348 XM_011530047 XP_011528349 XM_011530048 XP_011528350 XM_011530049 XP_011528351 XM_011530050 XP_011528352 XM_011530051 XP_011528353 NM_014337 NP_055152 NM_148175 NP_680480 NM_148176 NP_680481
Function	May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). {ECO:0000250|UniProtKB:Q08752, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000303|PubMed:8660300}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269|PubMed:15946952}.
Tissue Specificity	Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas. {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PPIL2 full length protein - ab167969 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source E. coli Species Human

Active human PPIL2 full length protein - ab93731 from Abcam Category Protein Prices $192.00 Sizes 25 µg Source E. coli Species Human

Active human PPIL2 full length protein - ab117682 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

PPIL2 / CYP60 Antibody Blocking Peptide - LS-E5681 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPIL2 / CYP60 Antibody Blocking Peptide - LS-E19858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPIL2 / CYP60 Antibody Blocking Peptide - LS-E19857 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PPIL2 Protein - NBP1-41225 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E. coli Species Human

PPIL2 Recombinant Protein - H00023759-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PPIL2 Recombinant Protein - P3502 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Species Human

PPIL2-Antibody-C-term-Blocking-Peptide - BP18215b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPIL2 Protein (OPPA02341) - OPPA02341 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human Peptidylprolyl Isomerase (Cyclophilin)-Like 2 protein - orb90237 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

Human PPIL2 protein (His Tag) - orb139508 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

PPIL2 Blocking Peptide - 33R-3545 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPIL2 Blocking Peptide - 33R-6143 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PPIL2 protein (His tag) - 80R-1269 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

PPIL2 (1-527, His-tag) - AR09397PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

PPIL2 (1-527, His-tag) - AR09397PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

PPIL2 - H00023759-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPIL2 - H00023759-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPIL2 - P3502 from Acris Antibodies Category Protein Prices $580.00 Sizes 50 µg Species Human

Cyclophilin-60, Human Recombinant - 228-12515-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Cyclophilin-60 - 228-12515-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Cyclophilin-60 - 228-12515-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

PPIL2, 1-527aa, Human, His tag, E.coli - 01-1795-2 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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