| Gene Symbol | EPHA3 |
|---|---|
| Entrez Gene | 2042 |
| Alt Symbol | EK4, ETK, ETK1, HEK, HEK4, TYRO4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A3 |
| Other Description | EPH-like kinase 4|TYRO4 protein tyrosine kinase|eph-like tyrosine kinase 1|ephrin type-A receptor 3|human embryo kinase 1|tyrosine-protein kinase receptor ETK1 |
| Swissprots | Q9H2V4 P29320 Q9H2V3 |
| Accessions | CAA01906 CAM91183 CAT16931 EAW68857 P29320 AF213459 AAG43576 AF213460 AAG43577 AK024352 AK291411 BAF84100 BC026247 BC063282 AAH63282 HM437236 ADN43067 M83941 AAA58633 XM_005264715 XP_005264772 XM_005264716 XP_005264773 NM_005233 NP_005224 NM_182644 NP_872585 |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed. Highest level in placenta. |
| Top Pathways | Axon guidance |