EPHA3

Gene Symbol	EPHA3
Entrez Gene	2042
Alt Symbol	EK4, ETK, ETK1, HEK, HEK4, TYRO4
Species	Human
Gene Type	protein-coding
Description	EPH receptor A3
Other Description	EPH-like kinase 4|TYRO4 protein tyrosine kinase|eph-like tyrosine kinase 1|ephrin type-A receptor 3|human embryo kinase 1|tyrosine-protein kinase receptor ETK1
Swissprots	Q9H2V4 P29320 Q9H2V3
Accessions	CAA01906 CAM91183 CAT16931 EAW68857 P29320 AF213459 AAG43576 AF213460 AAG43577 AK024352 AK291411 BAF84100 BC026247 BC063282 AAH63282 HM437236 ADN43067 M83941 AAA58633 XM_005264715 XP_005264772 XM_005264716 XP_005264773 NM_005233 NP_005224 NM_182644 NP_872585
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed. Highest level in placenta.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Eph receptor A3 protein fragment - ab84576 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human Eph receptor A3 full length protein - ab158369 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor A3 protein fragment - ab158370 from Abcam Category Protein Source Wheat germ Species Human

EPHA3 / EPH Receptor A3 Antibody Blocking Peptide - LS-E21457 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA3 / EPH Receptor A3 Antibody Blocking Peptide - LS-E9100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHA3 / EPH Receptor A3 Antibody Blocking Peptide - LS-E9101 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EphA3 Partial Recombinant Protein - H00002042-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EPH Receptor A3 Recombinant Protein - H00002042-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Recombinant Human EphA3 Protein - P4687 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

EphA3 Recombinant Protein - P4678 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EPH Receptor A3 Peptide - P2620 from Novus Biologicals Category Peptide Species Human

EPH Receptor A3 Peptide - P2619 from Novus Biologicals Category Peptide Species Human

EphA3-Antibody-C-term-Blocking-Peptide - BP7608b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EphA3-Antibody-N-term-Blocking-Peptide - BP7608a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human EphA3 Fc Chimera, CF - 6444-A3-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse EphA3 Fc Chimera, CF - 640-A3-200 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human EK4 protein - orb138773 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

EPHA3 (phospho-Tyr602) Blocking Peptide - abx064151 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig

EPHA3 Blocking Peptide - abx062585 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish

EPHA3 - H00002042-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EPHA3 - H00002042-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EPHA3 - H00002042-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHA3 - H00002042-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHA3 - P4678 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

EPHA3 - P4687 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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