| Gene Symbol | C14orf166 |
|---|---|
| Entrez Gene | 51637 |
| Alt Symbol | CGI-99, CGI99, CLE, CLE7, LCRP369, RLLM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromosome 14 open reading frame 166 |
| Other Description | CLE7 homolog|RLL motif containing 1|UPF0568 protein C14orf166 |
| Swissprots | Q9Y224 |
| Accessions | EAW65659 EAW65660 EAW65661 Q9Y224 AF087877 AAP97177 AF100755 AAD43019 AF151857 AAD34094 AK312004 BAG34942 AY817175 AAV54070 BC001722 AAH01722 BF594675 DQ525179 ABF56619 EU446806 ABZ92335 NM_016039 NP_057123 |
| Function | RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA- splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). {ECO:0000269|PubMed:16950395, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:24870230}. |
| Subcellular Location | Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:24608264}. |
| Tissue Specificity | Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. {ECO:0000269|PubMed:15147888}. |