| Gene Symbol |
KIAA1524
|
| Entrez Gene |
57650
|
| Alt Symbol |
CIP2A, p90
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KIAA1524
|
| Other Description |
cancerous inhibitor of PP2A|cancerous inhibitor of protein phosphatase 2A|p90 autoantigen|protein CIP2A
|
| Swissprots |
A1L4J7 Q8TCG1 Q9P204 Q9H9C6 Q8WVP8 Q6P4G6 B9EGC3 Q96PI2
|
| Accessions |
EAW79723 EAW79724 Q8TCG1 AB040957 BAA96048 AF334474 AAL11632 AK022912 BAB14305 AK056933 AK308315 AK310446 AL713689 CAD28489 AM393250 CAL38128 BC017659 AAH17659 BC063433 AAH63433 BC082961 BC130564 AAI30565 BC136371 AAI36372 XM_006713716 XP_006713779 XM_006713717 XP_006713780 XM_011513056 XP_011511358 XM_011513057 XP_011511359 NM_020890 NP_065941
|
| Function |
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. {ECO:0000269|PubMed:17632056}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12118381}. Note=Slightly concentrates in the perinuclear region.
|
| Tissue Specificity |
Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:17632056}.
|
![Western Blot: CIP2A Overexpression Lysate (Adult Normal) [NBL1-12266] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CIP2A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11088_CIP2A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12266-img0002.jpg)