Gene Symbol | KIAA1524 |
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Entrez Gene | 57650 |
Alt Symbol | CIP2A, p90 |
Species | Human |
Gene Type | protein-coding |
Description | KIAA1524 |
Other Description | cancerous inhibitor of PP2A|cancerous inhibitor of protein phosphatase 2A|p90 autoantigen|protein CIP2A |
Swissprots | A1L4J7 Q8TCG1 Q9P204 Q9H9C6 Q8WVP8 Q6P4G6 B9EGC3 Q96PI2 |
Accessions | EAW79723 EAW79724 Q8TCG1 AB040957 BAA96048 AF334474 AAL11632 AK022912 BAB14305 AK056933 AK308315 AK310446 AL713689 CAD28489 AM393250 CAL38128 BC017659 AAH17659 BC063433 AAH63433 BC082961 BC130564 AAI30565 BC136371 AAI36372 XM_006713716 XP_006713779 XM_006713717 XP_006713780 XM_011513056 XP_011511358 XM_011513057 XP_011511359 NM_020890 NP_065941 |
Function | Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation. {ECO:0000269|PubMed:17632056}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12118381}. Note=Slightly concentrates in the perinuclear region. |
Tissue Specificity | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:17632056}. |
CIP2A CRISPR/Cas9 KO Plasmid (h) - sc-401363 from Santa Cruz Biotechnology
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CIP2A HDR Plasmid (h) - sc-401363-HDR from Santa Cruz Biotechnology
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CIP2A Double Nickase Plasmid (h) - sc-401363-NIC from Santa Cruz Biotechnology
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CIP2A Double Nickase Plasmid (h2) - sc-401363-NIC-2 from Santa Cruz Biotechnology
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CIP2A CRISPR Activation Plasmid (h) - sc-401363-ACT from Santa Cruz Biotechnology
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CIP2A CRISPR Activation Plasmid (h2) - sc-401363-ACT-2 from Santa Cruz Biotechnology
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CIP2A Lentiviral Activation Particles (h) - sc-401363-LAC from Santa Cruz Biotechnology
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CIP2A Lentiviral Activation Particles (h2) - sc-401363-LAC-2 from Santa Cruz Biotechnology
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CIP2A siRNA (h) - sc-77964 from Santa Cruz Biotechnology
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CIP2A shRNA Plasmid (h) - sc-77964-SH from Santa Cruz Biotechnology
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CIP2A shRNA (h) Lentiviral Particles - sc-77964-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11137 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11137 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06120 from Sigma-Aldrich
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KIAA1524 siRNA (Human) - CRJ1608 from Cohesion Biosciences
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shRNA set against Human KIAA1524 (NM_020890.2) - SHH324807 from Creative biogene
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Human KIAA1524 siRNA - orb272109 from Biorbyt
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KIAA1524 shRNA Plasmid (Human) - CHJ1608 from Cohesion Biosciences
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KIAA1524 miRNA 3'UTR clone - MiUTR3H-11386 from Creative biogene
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