| Gene Symbol |
ROBO1
|
| Entrez Gene |
6091
|
| Alt Symbol |
DUTT1, SAX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
roundabout, axon guidance receptor, homolog 1 (Drosophila)
|
| Other Description |
deleted in U twenty twenty|roundabout homolog 1
|
| Swissprots |
Q9BUS7 B2RXI1 Q9Y6N7 Q7Z300 Q1RMC7 E9PD49 D3DU36
|
| Accessions |
EAW68884 EAW68885 EAW68886 EAW68887 EAW68888 Q9Y6N7 AF040990 AAC39575 AK025535 AK095256 AK297481 BAG59902 AK299920 BAH13173 BC001969 AAH01969 BC029676 BC112336 AAI12337 BC115020 AAI15021 BC115022 AAI15023 BC157861 AAI57862 BC171855 AAI71855 BP228659 BX538319 CAD98093 DR003097 XM_006713276 XP_006713339 XM_006713277 XP_006713340 XM_011533976 XP_011532278 XM_011533977 XP_011532279 XM_011533978 XP_011532280 XM_011533979 XP_011532281 XM_011533980 XP_011532282 NM_001145845 NP_001139317 NM_002941 NP_002932 NM_133631 NP_598334
|
| Function |
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. {ECO:0000269|PubMed:10102268}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed, with exception of kidney. {ECO:0000269|PubMed:9608531}.
|
| Top Pathways |
Axon guidance
|