Gene Symbol | PRPF4 |
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Entrez Gene | 9128 |
Alt Symbol | HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60 |
Species | Human |
Gene Type | protein-coding |
Description | pre-mRNA processing factor 4 |
Other Description | PRP4 homolog|PRP4 pre-mRNA processing factor 4 homolog|PRP4/STK/WD splicing factor|U4/U6 small nuclear ribonucleoprotein Prp4|U4/U6 snRNP 60 kDa protein|WD splicing factor Prp4 |
Swissprots | O43445 Q96IK4 O43172 Q96DG2 O43864 Q5T1M8 |
Accessions | AAB87640 EAW87362 EAW87363 O43172 AB209797 BAD93034 AF016369 AAC51925 AK225056 AK313131 BAG35951 AW052006 AY572489 AAS78572 BC001588 AAH01588 BC007424 AAH07424 CA420073 CR457105 CAG33386 DA815191 EU176331 ABW03782 EU176673 ABW03474 U82756 AAC02261 XM_005252300 XP_005252357 XM_011519181 XP_011517483 NM_001244926 NP_001231855 NM_004697 NP_004688 |
Function | Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. |
Subcellular Location | Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}. |
Top Pathways | Spliceosome |
PRPF4 CRISPR/Cas9 KO Plasmid (h) - sc-409732 from Santa Cruz Biotechnology
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PRPF4 HDR Plasmid (h) - sc-409732-HDR from Santa Cruz Biotechnology
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PRPF4 Double Nickase Plasmid (h) - sc-409732-NIC from Santa Cruz Biotechnology
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PRPF4 Double Nickase Plasmid (h2) - sc-409732-NIC-2 from Santa Cruz Biotechnology
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PRPF4 CRISPR Activation Plasmid (h) - sc-409732-ACT from Santa Cruz Biotechnology
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PRPF4 CRISPR Activation Plasmid (h2) - sc-409732-ACT-2 from Santa Cruz Biotechnology
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PRPF4 Lentiviral Activation Particles (h) - sc-409732-LAC from Santa Cruz Biotechnology
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PRPF4 Lentiviral Activation Particles (h2) - sc-409732-LAC-2 from Santa Cruz Biotechnology
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PRPF4 siRNA (h) - sc-92543 from Santa Cruz Biotechnology
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PRPF4 shRNA Plasmid (h) - sc-92543-SH from Santa Cruz Biotechnology
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PRPF4 shRNA (h) Lentiviral Particles - sc-92543-V from Santa Cruz Biotechnology
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PRPF4 RNAi - H00009128-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17477 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17477 from Sigma-Aldrich
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PRPF4 siRNA (Human) - CRH6035 from Cohesion Biosciences
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shRNA set against Human PRPF4 (NM_004697.4) - SHH383776 from Creative biogene
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PRPF4 shRNA Plasmid (Human) - CHH6035 from Cohesion Biosciences
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PRPF4 miRNA 3'UTR clone - MiUTR3H-09472 from Creative biogene
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