VAMP8

Gene Symbol	VAMP8
Entrez Gene	8673
Alt Symbol	EDB, VAMP-8
Species	Human
Gene Type	protein-coding
Description	vesicle-associated membrane protein 8
Other Description	vesicle-associated membrane protein 8 (endobrevin)
Swissprots	Q6IB09 O60625 Q9BV40 Q53SP9
Accessions	AAY24341 EAW99506 Q9BV40 AF053233 AAC08434 BC001634 AAH01634 BM702226 BQ227618 BT006700 AAP35346 BX092149 CD367710 CR456995 CAG33276 NM_003761 NP_003752
Function	SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709}.
Subcellular Location	Lysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.
Tissue Specificity	Platelets.
Top Pathways	SNARE interactions in vesicular transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VAMP8 Antibody - 13060 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

endobrevin (G-12) - sc-166820 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

endobrevin (T-20) - sc-19367 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

endobrevin (C-16) - sc-19368 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-VAMP8 antibody - ab6186 from Abcam Prices $384.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-VAMP8 antibody - ab81025 from Abcam Host Rabbit Clonality Polyclonal

Anti-VAMP8 antibody - ab89158 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-VAMP8 antibody - ab171008 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-VAMP8 antibody [1414CT354.12.23.93] - N-terminal - ab202347 from Abcam Prices $359.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 1414CT354.12.23.93

Anti-VAMP8 antibody [EP2629Y] - ab76021 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP2629Y

Anti-VAMP8 / VAMP-8 Antibody (Internal) - LS-C95270 from LifeSpan Bioscience Prices $325.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (N-Terminus) - LS-C144616 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (aa1-50) - LS-C290985 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (aa30-79) - LS-C145343 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (aa40-89) - LS-C170316 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (N-Terminus, clone EP2629Y) - LS-C105345 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP2629Y

Anti-VAMP8 / VAMP-8 Antibody (aa1-30) - LS-C344182 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-VAMP8 / VAMP-8 Antibody (aa2-24, clone 1414CT354.12.23.93) - LS-C344576 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 1414CT354.12.23.93

VAMP-8 Antibody (EP2629Y) - NBP1-40484 from Novus Biologicals Prices $399.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP2629Y

VAMP-8 Antibody [Unconjugated] - AF5354 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

VAMP-8 Antibody - NBP1-84013 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

VAMP-8 Antibody - H00008673-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

VAMP-8 Antibody - NBP1-46445 from Novus Biologicals Prices $299.00 Sizes 100 µl Host Goat Clonality Polyclonal

VAMP-8 Antibody - NBP1-20232 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

VAMP-8 Antibody - NBP2-32095 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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