VAMP8

Gene Symbol	VAMP8
Entrez Gene	8673
Alt Symbol	EDB, VAMP-8
Species	Human
Gene Type	protein-coding
Description	vesicle-associated membrane protein 8
Other Description	vesicle-associated membrane protein 8 (endobrevin)
Swissprots	Q6IB09 O60625 Q9BV40 Q53SP9
Accessions	AAY24341 EAW99506 Q9BV40 AF053233 AAC08434 BC001634 AAH01634 BM702226 BQ227618 BT006700 AAP35346 BX092149 CD367710 CR456995 CAG33276 NM_003761 NP_003752
Function	SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709}.
Subcellular Location	Lysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}.
Tissue Specificity	Platelets.
Top Pathways	SNARE interactions in vesicular transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VAMP8 full length protein - ab131768 from Abcam Category Protein Source Wheat germ Species Human

Human VAMP8 protein fragment - ab79141 from Abcam Category Protein Source E. coli Species Human

VAMP8 / VAMP-8 Antibody Blocking Peptide - LS-E21784 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAMP8 / VAMP-8 Antibody Blocking Peptide - LS-E21785 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VAMP-8 Recombinant Protein - H00008673-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human VAMP-8 Protein - NBC1-18348 from Novus Biologicals Category Protein Prices $369.00 Sizes 100 µg Source E. coli Species Human

VAMP8 Protein (OPPA01841) - OPPA01841 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human VAMP8 protein - orb81464 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

VAMP8 protein (His tag) - 80R-1081 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

VAMP-8 / Endobrevin (1-76, His-tag) - AR09094PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

VAMP-8 / Endobrevin (1-76, His-tag) - AR09094PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

VAMP-8 / Endobrevin - H00008673-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VAMP-8 / Endobrevin - H00008673-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Endobrevin, Human Recombinant - 228-11609-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human VAMP8 - 228-11609-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human VAMP8 - 228-11609-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

VAMP8, 1-76aa, Human, His tagged, Recombinant, E.coli - 01-2034 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Source E.coli Species Human

VAMP8 fusion protein - Ag7903 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

VAMP8 fusion protein - ag8381 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

VAMP8 Human - PRPS-667 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Vesicle-associated membrane protein 8 - BP002048-PRO-660 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

VAMP8, 1-76aa, Recombinant Protein - GWB-P0013M from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Synaptobrevin-8 - GWB-D0481C from Genway Biotech Category Protein Prices $75.00, $165.00, $4,035.00 Sizes 5 μg, 25 μg, 1000 μg Species Human

Recombinant Human VAMP8, His-tagged - VAMP8-30990TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Vesicle-associated Membrane Protein 8 (Endobrevin) - VAMP8-304H from Creative Biomart Category Protein Source E.coli.

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