| Gene Symbol | VAMP8 |
|---|---|
| Entrez Gene | 8673 |
| Alt Symbol | EDB, VAMP-8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | vesicle-associated membrane protein 8 |
| Other Description | vesicle-associated membrane protein 8 (endobrevin) |
| Swissprots | Q6IB09 O60625 Q9BV40 Q53SP9 |
| Accessions | AAY24341 EAW99506 Q9BV40 AF053233 AAC08434 BC001634 AAH01634 BM702226 BQ227618 BT006700 AAP35346 BX092149 CD367710 CR456995 CAG33276 NM_003761 NP_003752 |
| Function | SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. {ECO:0000269|PubMed:12130530, ECO:0000269|PubMed:23217709}. |
| Subcellular Location | Lysosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Platelets. |
| Top Pathways | SNARE interactions in vesicular transport |