PIWIL4

Gene Symbol	PIWIL4
Entrez Gene	143689
Alt Symbol	HIWI2, MIWI2
Species	Human
Gene Type	protein-coding
Description	piwi-like RNA-mediated gene silencing 4
Other Description	piwi-like 4|piwi-like protein 4
Swissprots	Q8N9V8 Q68CZ4 B4DEG5 Q8NEH2 Q8N8G9 Q7Z3Z4
Accessions	EAW66940 EAW66941 Q7Z3Z4 AB079366 BAC81341 AF086344 AK093475 BAC04179 AK096837 BAC04873 AK293616 BAG57076 BC031060 AAH31060 CR749642 CAH18436 DB091271 DQ891240 ABM82166 DQ894425 ABM85351 NM_152431 NP_689644
Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromat
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in testis. According to PubMed:17544373, it is ubiquitously expressed. {ECO:0000269|PubMed:17544373}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse PIWIL4 peptide - ab23535 from Abcam Category Peptide

HIWI2 / PIWIL4 Antibody Blocking Peptide - LS-E19093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIWI2 / PIWIL4 Antibody Blocking Peptide - LS-E19094 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIWIL4 Blocking Peptide - 33R-5441 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIWIL4 Blocking Peptide - 33R-8482 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIWIL4 fusion protein - ag3613 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Piwi-like protein 4(PIWIL4) ,partial - CSB-YP767195HU CSB-EP767195HU CSB-BP767195HU CSB-MP767195HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIWIL4 Protein - abx163030 from Abbexa Category Protein Species Human

PIWIL4 - TP306117 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Piwi-like protein 4 (PIWIL4), partial, Recombinant Protein - MBS1373342 from MyBioSource Category Protein Prices $1,005.00, $1,070.00, $1,195.00, $1,360.00, $1,445.00, $1,450.00, $1,500.00, $1,515.00, $1,640.00, $2,130.00, $2,165.00, $2,175.00, $2,495.00, $2,845.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 50 µg (Mammalian-Cell), 200 µg (Yeast), 500 µg (E-Coli), 100 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PIWIL4 Recombinant Protein Antigen - NBP1-83491PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

PIWIL4 Recombinant Protein Antigen - NBP2-49258PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

PIWIL4 Peptide, Human - M34GP11831H from Creative Peptides Category Peptide Source Synthetic. Species Human

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