Gene Symbol | ARPC2 |
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Entrez Gene | 10109 |
Alt Symbol | ARC34, PNAS-139, PRO2446, p34-Arc |
Species | Human |
Gene Type | protein-coding |
Description | actin related protein 2/3 complex, subunit 2, 34kDa |
Other Description | ARP2/3 protein complex subunit 34|actin-related protein 2/3 complex subunit 2|arp2/3 complex 34 kDa subunit |
Swissprots | O15144 Q9P1D4 Q92801 |
Accessions | AAX93213 EAW70591 EAW70592 EAW70593 EAW70594 EAW70595 EAW70596 EAW70597 O15144 AF006085 AAB64190 AF279893 AAK07550 AK092520 AK093625 AK290268 BAF82957 BC000590 AAH00590 BG282181 BG765898 BT006898 AAP35544 CN291458 U50523 AAC50874 XM_011510470 XP_011508772 XM_011510471 XP_011508773 NM_005731 NP_005722 NM_152862 NP_690601 |
Function | Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Cell junction, synapse, synaptosome {ECO:0000250}. |
Top Pathways | Pathogenic Escherichia coli infection, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Regulation of actin cytoskeleton |
p34-ARC CRISPR/Cas9 KO Plasmid (h) - sc-405480 from Santa Cruz Biotechnology
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p34-ARC HDR Plasmid (h) - sc-405480-HDR from Santa Cruz Biotechnology
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p34-ARC Double Nickase Plasmid (h) - sc-405480-NIC from Santa Cruz Biotechnology
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p34-ARC Double Nickase Plasmid (h2) - sc-405480-NIC-2 from Santa Cruz Biotechnology
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p34-ARC CRISPR Activation Plasmid (h) - sc-405480-ACT from Santa Cruz Biotechnology
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p34-ARC CRISPR Activation Plasmid (h2) - sc-405480-ACT-2 from Santa Cruz Biotechnology
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p34-ARC Lentiviral Activation Particles (h) - sc-405480-LAC from Santa Cruz Biotechnology
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p34-ARC Lentiviral Activation Particles (h2) - sc-405480-LAC-2 from Santa Cruz Biotechnology
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p34-ARC siRNA (h) - sc-106767 from Santa Cruz Biotechnology
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p34-ARC shRNA Plasmid (h) - sc-106767-SH from Santa Cruz Biotechnology
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p34-ARC shRNA (h) Lentiviral Particles - sc-106767-V from Santa Cruz Biotechnology
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ARPC2 RNAi - H00010109-R01 from Novus Biologicals
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ARPC2 RNAi - H00010109-R02 from Novus Biologicals
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MISSION® esiRNA - EHU077951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3527 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3527 from Sigma-Aldrich
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ARPC2 siRNA (Human) - CRH6815 from Cohesion Biosciences
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ARPC2 - MBS8206342 from MyBioSource
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shRNA set against Human ARPC2(NM_005731.2) - SHG067865 from Creative biogene
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Human ARPC2 siRNA - orb267317 from Biorbyt
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ARPC2 shRNA Plasmid (Human) - CHH6815 from Cohesion Biosciences
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ARPC2 miRNA 3'UTR clone - MiUTR1H-00592 from Creative biogene
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ARPC2 miRNA 3'UTR clone - MiUTR3H-06658 from Creative biogene
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