ARRB2

Gene Symbol	ARRB2
Entrez Gene	409
Alt Symbol	ARB2, ARR2, BARR2
Species	Human
Gene Type	protein-coding
Description	arrestin, beta 2
Other Description	arrestin 3|arrestin beta-2|beta-arrestin-2
Swissprots	P32121 Q8N7Y2 Q2PP19 Q0Z8D3 Q6ICT3 B4DLW0 B5B0C0 Q9UEQ6 H0Y688 B7WPL3 D3DTK2
Accessions	ABC40725 CCQ43257 EAW90419 EAW90420 EAW90421 EAW90422 P32121 AB209786 BAD93023 AF106941 AAC99468 AK097542 BAC05094 AK290951 BAF83640 AK297059 BAG59581 AK297181 BAG59672 BC007427 AAH07427 BC039066 BC067368 AAH67368 BC095450 BG723452 CR450310 CAG29306 CR749218 CAH18075 DQ664180 ABG47460 DQ893226 ABM84152 DQ896556 ABM87555 EU176778 ABW03579 EU883572 ACG60646 Z11501 CAA77577 XM_006721520 XP_006721583 XM_006721521 XP_006721584 XM_011523858 XP_011522160 XM_011523859 XP_011522161 NM_001257328 NP_001244257 NM_001257329 NP_001244258 NM_001257330 NP_001244259 NM_001257331 NP_001244260 NM_004313 NP_004304 NM_199004 NP_945355 NR_047516
Function	Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
Top Pathways	Olfactory transduction, MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ARRB2 / Beta Arrestin 2 ELISA Kit (Sandwich ELISA) - LS-F5814 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 6.4 pg/ml Range 15.63-1000 pg/ml

Arrestin Beta 2, ARRb2, Human, ELISA Kit - E-EL-H0503 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Arrestin Beta 2 (ARRb2), Human, ELISA Kit - SEB994Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 6.4pg/mL Range 15.6-1,000pg/mL

Beta-arrestin-2 (ARRB2), Human, ELISA Kit - CSB-EL002135HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Beta-arrestin-2, ARRB2, Human, ELISA Kit - E1994h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Arrestin Beta 2, ARRb2, Rabbit, ELISA Kit - E-EL-RB0786 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arrestin Beta 2, ARRb2, Chicken, ELISA Kit - E-EL-Ch0399 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Arrestin Beta 2, ARRb2, Porcine, ELISA Kit - E-EL-P2014 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Arrestin Beta 2, ARRb2, Monkey, ELISA Kit - E-EL-MK1968 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

arrestin, beta 2, ELISA Kit - MBS940533 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ARRB2 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml-1600 pg/ml.

Human ARRB2 ELISA Kit - DEIA3179 from Creative Diagnostics Category ELISA Kit Range 0.156-10 ng/mL.

Arrestin Beta 2 (ARRb2) - MBS9308565 from MyBioSource Category ELISA Kit

beta-arrestin 2, ARRB2, ELISA Kit - MBS9301192 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

beta-arrestin 2, ARRB2, ELISA Kit - MBS9301195 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml. Range 31.2 pg/ml - 1000 pg/ml.

ELISA Kit for Arrestin Beta 2 (ARRb2) - SEB994Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.4pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Human Beta-arrestin-2(ARRB2) ELISA kit - CSB-EL002135HU from Cusabio Category ELISA Kit Sensitivity 6.25pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Arrestin Beta 2 (ARRb2) - SEB994Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.4pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

Bovine ARRB2 / Beta Arrestin 2 ELISA Kit (Custom ELISA) - LS-F18998 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 15.63-1000 pg/ml

Rat ARRB2 / Beta Arrestin 2 ELISA Kit (Custom ELISA) - LS-F18997 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 15.63-1000 pg/ml

Mouse ARRB2 / Beta Arrestin 2 ELISA Kit (Custom ELISA) - LS-F18999 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 15.63-1000 pg/ml

Beta-arrestin-2, ELISA Kit - MBS288327 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.78 ng/ml -50.0 ng/ml.

Beta-arrestin-2, ELISA Kit - MBS288411 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15 ng/ml -10.0 ng/ml.

Human ARRBeta2(Arrestin Beta 2) ELISA Kit - E-EL-H0503 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 18.75 pg/mLpg/mL Range 31.25~2000 pg/mL

Human Beta-arrestin-2 ELISA Kit - abx251362 from Abbexa Category ELISA Kit Sensitivity 37.5 pg/ml Range 62.5 pg/ml - 4000 pg/ml

Human ARRB2 / Beta Arrestin 2 ELISA Kit (Sandwich ELISA) - LS-F23425 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 18.75 pg/ml Range 15.63-1000 pg/ml

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