ARRB2

Gene Symbol ARRB2
Entrez Gene 409
Alt Symbol ARB2, ARR2, BARR2
Species Human
Gene Type protein-coding
Description arrestin, beta 2
Other Description arrestin 3|arrestin beta-2|beta-arrestin-2
Swissprots P32121 Q8N7Y2 Q2PP19 Q0Z8D3 Q6ICT3 B4DLW0 B5B0C0 Q9UEQ6 H0Y688 B7WPL3 D3DTK2
Accessions ABC40725 CCQ43257 EAW90419 EAW90420 EAW90421 EAW90422 P32121 AB209786 BAD93023 AF106941 AAC99468 AK097542 BAC05094 AK290951 BAF83640 AK297059 BAG59581 AK297181 BAG59672 BC007427 AAH07427 BC039066 BC067368 AAH67368 BC095450 BG723452 CR450310 CAG29306 CR749218 CAH18075 DQ664180 ABG47460 DQ893226 ABM84152 DQ896556 ABM87555 EU176778 ABW03579 EU883572 ACG60646 Z11501 CAA77577 XM_006721520 XP_006721583 XM_006721521 XP_006721584 XM_011523858 XP_011522160 XM_011523859 XP_011522161 NM_001257328 NP_001244257 NM_001257329 NP_001244258 NM_001257330 NP_001244259 NM_001257331 NP_001244260 NM_004313 NP_004304 NM_199004 NP_945355 NR_047516
Function Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors,
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
Top Pathways Olfactory transduction, MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction

β-Arrestin 2 (C16D9) Rabbit mAb - 3857 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C16D9
Western blot analysis of extracts from various cell lines using β-Arrestin 2 (C16D9) Rabbit mAb.

β-Arrestin-2 (C-18) - sc-6387 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-2 (C-18): sc-6387. Western blot analysis of β-Arrestin-2 expression in non-transfected: sc-117752 (A) and human β-Arrestin-2 transfected: sc-116903 (B) 293T whole cell lysates.

β-Arrestin-2 (D-18) - sc-30938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-2 (D-18): sc-30938. Western blot analysis of β-Arrestin-2 expression in non-transfected: sc-117752 (A) and human β-Arrestin-2 transfected: sc-116903 (B) 293T whole cell lysates.

β-Arrestin-2 (D-5) - sc-166935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β-Arrestin-2 (D-5): sc-166935. Western blot analysis of β-Arrestin-2 expression in non-transfected: sc-117752 (A) and human β-Arrestin-2 transfected: sc-116903 (B) 293T whole cell lysates.

β-Arrestin-2 (H-47) - sc-98833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
β-Arrestin-2 (H-47): sc-98833. Western blot analysis of β-Arrestin-2 expression in non-transfected: sc-117752 (A) and mouse β-Arrestin-2 transfected: sc-110713 (B) 293T whole cell lysates.

β-Arrestin-2 (H-9) - sc-13140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
β-Arrestin-2 (H-9): sc-13140. Western blot analysis of β-Arrestin-2 expression in RAW 264.7 (A) and PC-12 (B) whole cell lysates.

β-Arrestin-2 (N-16) - sc-6386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-2 (N-16): sc-6386. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human spleen tissue showing membrane and cytoplasmic staining.

β-Arrestin-2 (P-17) - sc-30936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-Arrestin-2 (P-17): sc-30936. Western blot analysis of β-Arrestin-2 expression in non-transfected: sc-117752 (A) and human β-Arrestin-2 transfected: sc-176496 (B) 293T whole cell lysates.

Anti-Beta Arrestin 2 antibody - ab54790 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Beta Arrestin 2 antibody (ab54790) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-Beta Arrestin 2 antibody - ab31294 from Abcam

Prices $400.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab31294 immunoprecipitating Beta Arrestin 2 in mouse heart whole cell lysate. 50µg of cell lysate was incubated with primary antibody (undiluted) and matrix (Protein A/G Magnetic Beads) for 45 minutes. For western blotting a rabbit anti-Beta Arrestin 2 monoclonal antibody and HRP-conjugated anti-rabbit IgG secondary antibody were used to confirm successful immunoprecipation.See Abreview

Anti-Beta Arrestin 2 antibody - ab167047 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thyroid tissue labeling Beta Arrestin 2 with ab167047 at 5 µg/ml.

Anti-Beta Arrestin 2 antibody - ab138421 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling Beta Arrestin 2 with ab138421 at 1/1000 (1µg/ml). Detection: DAB.

Anti-Beta Arrestin 2 antibody - ab77208 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Immunofluorescent analysis of HeLa cells using ab77208 at 10 ug/ml.

Anti-Beta Arrestin 2 antibody - ab151774 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human intestinal cancer tissue, labeling Beta Arrestin 2 wth ab151774 at 1 μg/ml .

Anti-Beta Arrestin 2 antibody - ab137249 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling Beta Arrestin 2 with ab137249 at 1/1000 (1µg/ml). Detection: DAB.

Anti-Beta Arrestin 2 antibody [3G1] - ab124291 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3G1
ab124291, at 5 µg/ml, staining Beta Arrestin 2 in paraffin-embedded Human thymus tissue by immunohistochemistry.

Anti-Beta Arrestin 2 antibody - N-terminal - ab200156 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Beta Arrestin 2 antibody - N-terminal (ab200156) at 1/1000 dilutionLane 1 : Mouse brain tissue extractLane 2 : Mouse thymus tissue extract

Anti-ARRB2 / Beta Arrestin 2 Antibody - LS-C69276 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody (aa384-397) - LS-C69277 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody - LS-C96198 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody (aa281-298) - LS-C148990 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody - LS-C155162 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody (aa262-430, FITC) - LS-C303425 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody (aa262-430, Biotin) - LS-C297847 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ARRB2 / Beta Arrestin 2 Antibody (aa351-361) - LS-C54486 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.03 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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