| Gene Symbol | ARRB2 |
|---|---|
| Entrez Gene | 409 |
| Alt Symbol | ARB2, ARR2, BARR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arrestin, beta 2 |
| Other Description | arrestin 3|arrestin beta-2|beta-arrestin-2 |
| Swissprots | P32121 Q8N7Y2 Q2PP19 Q0Z8D3 Q6ICT3 B4DLW0 B5B0C0 Q9UEQ6 H0Y688 B7WPL3 D3DTK2 |
| Accessions | ABC40725 CCQ43257 EAW90419 EAW90420 EAW90421 EAW90422 P32121 AB209786 BAD93023 AF106941 AAC99468 AK097542 BAC05094 AK290951 BAF83640 AK297059 BAG59581 AK297181 BAG59672 BC007427 AAH07427 BC039066 BC067368 AAH67368 BC095450 BG723452 CR450310 CAG29306 CR749218 CAH18075 DQ664180 ABG47460 DQ893226 ABM84152 DQ896556 ABM87555 EU176778 ABW03579 EU883572 ACG60646 Z11501 CAA77577 XM_006721520 XP_006721583 XM_006721521 XP_006721584 XM_011523858 XP_011522160 XM_011523859 XP_011522161 NM_001257328 NP_001244257 NM_001257329 NP_001244258 NM_001257330 NP_001244259 NM_001257331 NP_001244260 NM_004313 NP_004304 NM_199004 NP_945355 NR_047516 |
| Function | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. |
| Top Pathways | Olfactory transduction, MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction |