| Gene Symbol | INPP5B |
|---|---|
| Entrez Gene | 3633 |
| Alt Symbol | 5PTase |
| Species | Human |
| Gene Type | protein-coding |
| Description | inositol polyphosphate-5-phosphatase, 75kDa |
| Other Description | phosphoinositide 5-phosphatase|type II inositol 1,4,5-trisphosphate 5-phosphatase |
| Swissprots | Q658Q5 C9J6U5 P32019 Q5VSH0 Q6P6D4 Q6PD53 Q86YE1 Q5VSH1 Q5VSG9 |
| Accessions | EAX07307 EAX07308 EAX07309 EAX07310 EAX07311 P32019 AK022846 BAG51126 AK093261 AK295062 BAG58111 AK310824 AL833055 CAH56301 BC042529 AAH42529 BC058932 AAH58932 BC062317 DA125087 DC398675 M74161 AAA79207 XM_005270835 XP_005270892 XM_006710619 XP_006710682 XM_006710621 XP_006710684 XM_011541387 XP_011539689 XM_011541388 XP_011539690 XM_011541389 XP_011539691 XM_011541390 XP_011539692 XM_011541391 XP_011539693 XM_011541392 XP_011539694 XM_011541393 XP_011539695 XR_946643 XR_946644 NM_001297434 NP_001284363 NM_005540 NP_005531 |
| Function | Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}. |
| Subcellular Location | Cytoplasm, cytosol. Endoplasmic reticulum- Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Golgi apparatus. |
| Tissue Specificity | Platelets. |
| Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |