MYO10

Gene Symbol MYO10
Entrez Gene 4651
Alt Symbol -
Species Human
Gene Type protein-coding
Description myosin X
Other Description myosin-X|unconventional myosin-10|unconventional myosin-X|unconventionnal myosin-X
Swissprots Q9P111 O94893 Q9HD67 Q9UHF6 Q9P110 Q8IVX5 A7E2D1 Q9NYM7
Accessions EAX08016 EAX08017 EAX08018 Q9HD67 AB018342 BAA34519 AF132021 AAF36524 AF132022 AAF36525 AF184153 AAF17363 AF234532 AAF37875 AF247457 AAF68025 AI086647 AK001501 AK024719 AK025921 AK074717 BAC11158 AK125246 AK295630 BAG58507 AK295736 BAH12170 AK303459 BAG64502 AK316138 BAH14509 AL832428 CAH10611 BC014956 BC032669 BC041694 AAH41694 BC050682 AAH50682 BC071965 AAH71965 BC094838 AAH94838 BC108736 AAI08737 BC137168 AAI37169 BC150285 AAI50286 CA488271 DA504301 XM_005248306 XP_005248363 XM_005248307 XP_005248364 XM_006714475 XP_006714538 XM_011514046 XP_011512348 NM_012334 NP_036466
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:10984435}. Cell projection, lamellipodium {ECO:0000269|PubMed:10984435}. Cell projection, ruffle {ECO:0000269|PubMed:10984435}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10984435}. Cell projection, filopodium tip {ECO:0000269|PubMed:10984435}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10984435}. Cell projection, filopodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10984435}.
Top Pathways Fc gamma R-mediated phagocytosis

Myosin X (C-1) - sc-166720 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Myosin X (C-1): sc-166720. Western blot analysis of Myosin X expression in C32 (A), T24 (B) and Sol8 (C) whole cell lysates.

Myosin X (H-300) - sc-30177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Myosin X (H-300): sc-30177. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

Myosin X (N-14) - sc-23137 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Myosin X (N-14): sc-23137. Western blot analysis of Myosin X expression in KNRK whole cell lysate.

Anti-MYO10 antibody - ab58699 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO10 / Myosin-X Antibody (C-Terminus) - LS-C46880 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO10 / Myosin-X Antibody (C-Terminus) - LS-C151658 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MYO10 / Myosin-X antibody Western Blot of 293T.

Anti-MYO10 / Myosin-X Antibody (Internal) IHC-plus™ - LS-B8137 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MYO10 / MYOSIN-X antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8137 dilution 5 ug/ml.

myosin X Antibody - 22430002 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: myosin X Antibody [22430002] - Detection of Myo10 in HeLa cells at a dilution of 1:800 with 1 mg/mL stock. The predicted molecular weight of MYO10, based on the amino acid sequence, is 237 kD. MYO10 appeared at approximately 250 kD on this gel.

myosin X Antibody - NBP1-87748 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: myosin X Antibody [NBP1-87748] - Staining of human cell line U-2 OS shows positivity in nucleoli, plasma membrane and cytoplasm. Antibody staining is shown in green.

Anti-MYO10 antibody produced in rabbit - HPA024223 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MYO10: <B>Cat. No. HPA024223</B>: Immunohistochemical staining of human skeletal muscle shows moderate cytopalsmic positivity in myocytes.

MYO10 antibody - C-terminal region (ARP64209_P050) - ARP64209_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Myosin-X antibody - 24565-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of SH-SY5Y cells using 24565-1-AP( MYO10 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Myosin-X antibody - PAB5466 from Acris Antibodies

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Myosin-X antibody - PAB5467 from Acris Antibodies

Prices $500.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MYO10 antibody - 24565-1-AP from Proteintech Group

Prices $279.00
Sizes con: 54 μg/150μl
Host Rabbit
Clonality Polyclonal
mouse brain tissue were subjected to SDS PAGE followed by western blot with 24565-1-AP( MYO10 Antibody) at dilution of 1:600

MYOD1, Monoclonal Antibody - MBS850471 from MyBioSource

Prices $290.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C8

MYO10 Antibody - GWB-MX104E from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit

Anti-MYO10 (C-terminal) polyclonal antibody - DPABH-16610 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

MYO10 / MYOSIN-X, Polyclonal Antibody - MBS242826 from MyBioSource

Prices $495.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Myosin X Antibody - AB1094 from EMD Millipore

Prices $316.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MYO10 Antibody (OALA06757) - OALA06757 from Aviva Systems Biology

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO10--Myosin-X-Antibody-Internal-ALS15314 - ALS15314 from Abgent, a WuXi AppTec company

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MYO10 / MYOSIN-X antibody IHC of human skeletal muscle.

Anti-MYO10 antibody - STJ110737 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

MYO10 - A8439 from NeoScientific

Prices $220.00, $380.00
Sizes 100 µl, 200 µl
Host Rabbit
Clonality Monoclonal
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