| Gene Symbol |
MYO10
|
| Entrez Gene |
4651
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin X
|
| Other Description |
myosin-X|unconventional myosin-10|unconventional myosin-X|unconventionnal myosin-X
|
| Swissprots |
Q9P111 O94893 Q9HD67 Q9UHF6 Q9P110 Q8IVX5 A7E2D1 Q9NYM7
|
| Accessions |
EAX08016 EAX08017 EAX08018 Q9HD67 AB018342 BAA34519 AF132021 AAF36524 AF132022 AAF36525 AF184153 AAF17363 AF234532 AAF37875 AF247457 AAF68025 AI086647 AK001501 AK024719 AK025921 AK074717 BAC11158 AK125246 AK295630 BAG58507 AK295736 BAH12170 AK303459 BAG64502 AK316138 BAH14509 AL832428 CAH10611 BC014956 BC032669 BC041694 AAH41694 BC050682 AAH50682 BC071965 AAH71965 BC094838 AAH94838 BC108736 AAI08737 BC137168 AAI37169 BC150285 AAI50286 CA488271 DA504301 XM_005248306 XP_005248363 XM_005248307 XP_005248364 XM_006714475 XP_006714538 XM_011514046 XP_011512348 NM_012334 NP_036466
|
| Function |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. {ECO:0000269|PubMed:16894163, ECO:0000269|PubMed:18570893}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:10984435}. Cell projection, lamellipodium {ECO:0000269|PubMed:10984435}. Cell projection, ruffle {ECO:0000269|PubMed:10984435}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10984435}. Cell projection, filopodium tip {ECO:0000269|PubMed:10984435}. Cytoplasm, cell cortex {ECO:0000269|PubMed:10984435}. Cell projection, filopodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=May be in an inactive, monomeric conformation in the cytosol. Detected in cytoplasmic punctae and in cell projections. Colocalizes with actin fibers. Undergoes forward and rearward movements within filopodia. Interacts with microtubules.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10984435}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis
|