| Gene Symbol |
BCOR
|
| Entrez Gene |
54880
|
| Alt Symbol |
ANOP2, MAA2, MCOPS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BCL6 corepressor
|
| Other Description |
BCL-6 corepressor|BCL-6 interacting corepressor
|
| Swissprots |
Q9H233 Q8TEB4 Q6P4B6 Q9H232 Q96DB3 Q9HCJ7 Q6W2J9 Q29RF6 D3DWB4 Q9NXF2 D3DWB3 Q7Z2K7
|
| Accessions |
EAW59425 EAW59426 EAW59427 EAW59428 EAW59429 EAW59430 Q6W2J9 AB046795 BAB13401 AF317391 AAG41429 AF317392 AAG41430 AK000292 BAA91061 AK056538 AK074286 BAB85037 AK095360 BAG53034 AK225581 AL698729 AY316592 AAR08265 BC009675 AAH09675 BC063536 AAH63536 BC114220 AAI14221 BC128387 AAI28388 BC128456 XM_005272616 XP_005272673 XM_005272618 XP_005272675 XM_005272619 XP_005272676 XM_005272620 XP_005272677 XM_006724536 XP_006724599 XM_011543929 XP_011542231 XM_011543930 XP_011542232 XM_011543931 XP_011542233 NM_001123383 NP_001116855 NM_001123384 NP_001116856 NM_001123385 NP_001116857 NM_017745 NP_060215 NM_001130139 NM_020926
|
| Function |
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). {ECO:0000269|PubMed:10898795, ECO:0000269|PubMed:15004558, ECO:0000269|PubMed:18280243, ECO:0000269|PubMed:19578371, ECO:0000269|PubMed:23911289}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10898795}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10898795}.
|