| Gene Symbol |
RHBDF2
|
| Entrez Gene |
79651
|
| Alt Symbol |
RHBDL5, RHBDL6, TEC, TOC, TOCG, iRhom2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
rhomboid 5 homolog 2 (Drosophila)
|
| Other Description |
inactive rhomboid protein 2|rhomboid family member 2|rhomboid veinlet-like protein 5|rhomboid veinlet-like protein 6
|
| Swissprots |
Q6PJF5 Q9H6E9 Q5YGQ8 Q5U607 A6NEM3 A8K801
|
| Accessions |
EAW89401 EAW89402 EAW89403 EAW89404 Q6PJF5 AK025994 BAB15310 AK057882 AK074034 BAB84860 AK225684 AK292135 BAF84824 AK292166 BAF84855 AK303434 BAH13960 AL833680 AY500247 AAS77567 BC016034 AAH16034 BC035829 AAH35829 BE076010 BM801831 BP284970 BP288209 DC337840 DC348660 XM_005257669 XP_005257726 XM_005257670 XP_005257727 XM_011525249 XP_011523551 XM_011525250 XP_011523552 XM_011525251 XP_011523553 XM_011525252 XP_011523554 NM_001005498 NP_001005498 NM_024599 NP_078875
|
| Function |
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:22265016}.
|
| Tissue Specificity |
Found in the epidermis and esophageal epithelium. {ECO:0000269|PubMed:22265016}.
|
![Western Blot: RHBDF2 Overexpression Lysate (Adult Normal) [NBL1-15344] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RHBDF2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2938_RHBDF2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15344-img0002.jpg)