Gene Symbol | CORO7 |
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Entrez Gene | 79585 |
Alt Symbol | 0610011B16Rik, CRN7, POD1 |
Species | Human |
Gene Type | protein-coding |
Description | coronin 7 |
Other Description | 70 kDa WD repeat tumor rejection antigen homolog|coronin-7 |
Swissprots | I3L416 Q17RK4 B4DFD6 B4DL18 P57737 |
Accessions | EAW85307 EAW85308 EAW85310 P57737 AK025674 BAB15211 AK094596 BAG52896 AK097238 BAG53439 AK126176 AK294045 BAG57397 AK296723 BAG59311 AK296807 BAG59380 AK303353 BAG64414 AK309327 AK309763 BC117289 AAI17290 BC117291 AAI17292 BM671637 DA094935 DR155527 HQ258676 ADR83427 NM_001201472 NP_001188401 NM_001201473 NP_001188402 NM_024535 NP_078811 |
Function | F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post- Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}. |
Subcellular Location | Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments. |
Tissue Specificity | Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. {ECO:0000269|PubMed:21130766}. |
Coronin 7 CRISPR/Cas9 KO Plasmid (h) - sc-416817 from Santa Cruz Biotechnology
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Coronin 7 HDR Plasmid (h) - sc-416817-HDR from Santa Cruz Biotechnology
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Coronin 7 Double Nickase Plasmid (h) - sc-416817-NIC from Santa Cruz Biotechnology
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Coronin 7 Double Nickase Plasmid (h2) - sc-416817-NIC-2 from Santa Cruz Biotechnology
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Coronin 7 CRISPR Activation Plasmid (h) - sc-416817-ACT from Santa Cruz Biotechnology
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Coronin 7 CRISPR Activation Plasmid (h2) - sc-416817-ACT-2 from Santa Cruz Biotechnology
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Coronin 7 Lentiviral Activation Particles (h) - sc-416817-LAC from Santa Cruz Biotechnology
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Coronin 7 Lentiviral Activation Particles (h2) - sc-416817-LAC-2 from Santa Cruz Biotechnology
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Coronin 7 siRNA (h) - sc-93115 from Santa Cruz Biotechnology
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Coronin 7 shRNA Plasmid (h) - sc-93115-SH from Santa Cruz Biotechnology
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Coronin 7 shRNA (h) Lentiviral Particles - sc-93115-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU005801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6458 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6458 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13012 from Sigma-Aldrich
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CORO7 siRNA (Human) - CRJ2408 from Cohesion Biosciences
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CORO7 - MBS8220307 from MyBioSource
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shRNA set against Human CORO7 (NM_024535.4) - SHH268117 from Creative biogene
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Human CORO7 siRNA - orb272909 from Biorbyt
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CORO7 shRNA Plasmid (Human) - CHJ2408 from Cohesion Biosciences
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CORO7 miRNA 3'UTR clone - MiUTR3H-12041 from Creative biogene
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