Gene Symbol | CHRNA6 |
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Entrez Gene | 8973 |
Alt Symbol | CHNRA6 |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, nicotinic, alpha 6 (neuronal) |
Other Description | acetylcholine receptor, nicotinic, alpha 6 (neuronal)|cholinergic receptor, nicotinic, alpha polypeptide 6|neuronal acetylcholine receptor subunit alpha-6 |
Swissprots | Q15825 B4DQH1 B2R8V4 |
Accessions | BAC06855 CCQ43252 EAW63207 Q15825 AK298798 BAG60933 AK313521 BAG36301 BC014456 AAH14456 DC307404 HQ448331 ADQ32811 U62435 AAB40113 Y16282 CAA76155 NM_001199279 NP_001186208 NM_004198 NP_004189 |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Top Pathways | Nicotine addiction, Neuroactive ligand-receptor interaction |
AChRα6 CRISPR/Cas9 KO Plasmid (h) - sc-405694 from Santa Cruz Biotechnology
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AChRα6 HDR Plasmid (h) - sc-405694-HDR from Santa Cruz Biotechnology
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AChRα6 Double Nickase Plasmid (h) - sc-405694-NIC from Santa Cruz Biotechnology
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AChRα6 Double Nickase Plasmid (h2) - sc-405694-NIC-2 from Santa Cruz Biotechnology
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AChRα6 CRISPR Activation Plasmid (h) - sc-405694-ACT from Santa Cruz Biotechnology
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AChRα6 CRISPR Activation Plasmid (h2) - sc-405694-ACT-2 from Santa Cruz Biotechnology
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AChRα6 Lentiviral Activation Particles (h) - sc-405694-LAC from Santa Cruz Biotechnology
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AChRα6 Lentiviral Activation Particles (h2) - sc-405694-LAC-2 from Santa Cruz Biotechnology
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AChRα6 siRNA (h) - sc-105031 from Santa Cruz Biotechnology
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AChRα6 shRNA Plasmid (h) - sc-105031-SH from Santa Cruz Biotechnology
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AChRα6 shRNA (h) Lentiviral Particles - sc-105031-V from Santa Cruz Biotechnology
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Nicotinic Acetylcholine R alpha 6/CHRNA6 RNAi - H00008973-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6098 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6098 from Sigma-Aldrich
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CHRNA6 siRNA (Human) - CRH5923 from Cohesion Biosciences
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CHRNA6 - MBS8234190 from MyBioSource
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shRNA set against Human CHRNA6 (NM_004198.3) - SHH263585 from Creative biogene
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Human CHRNA6 siRNA - orb266425 from Biorbyt
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CHRNA6 shRNA Plasmid (Human) - CHH5923 from Cohesion Biosciences
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