Gene Symbol | TMEFF1 |
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Entrez Gene | 8577 |
Alt Symbol | C9orf2, CT120.1, H7365, TR-1 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein with EGF-like and two follistatin-like domains 1 |
Other Description | cancer/testis antigen family 120, member 1|tomoregulin-1|transmembrane protein with EGF-like and one follistatin-like domain |
Swissprots | Q8N3T8 Q13086 Q8IYR6 |
Accessions | EAW58936 Q8IYR6 BC021991 BC035056 AAH35056 BF436262 DN602026 DQ891732 ABM82658 DQ894909 ABM85835 NM_003692 NP_003683 |
Function | May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. {ECO:0000250, ECO:0000269|PubMed:12743596}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:12743596}; Single-pass type I membrane protein {ECO:0000269|PubMed:12743596}. |
Tissue Specificity | Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues. {ECO:0000269|PubMed:12743596}. |
TMEFF1 CRISPR/Cas9 KO Plasmid (h) - sc-404818 from Santa Cruz Biotechnology
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TMEFF1 HDR Plasmid (h) - sc-404818-HDR from Santa Cruz Biotechnology
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TMEFF1 Double Nickase Plasmid (h) - sc-404818-NIC from Santa Cruz Biotechnology
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TMEFF1 Double Nickase Plasmid (h2) - sc-404818-NIC-2 from Santa Cruz Biotechnology
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TMEFF1 CRISPR Activation Plasmid (h) - sc-404818-ACT from Santa Cruz Biotechnology
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TMEFF1 CRISPR Activation Plasmid (h2) - sc-404818-ACT-2 from Santa Cruz Biotechnology
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TMEFF1 Lentiviral Activation Particles (h) - sc-404818-LAC from Santa Cruz Biotechnology
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TMEFF1 Lentiviral Activation Particles (h2) - sc-404818-LAC-2 from Santa Cruz Biotechnology
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TMEFF1 siRNA (h) - sc-45762 from Santa Cruz Biotechnology
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TMEFF1 shRNA Plasmid (h) - sc-45762-SH from Santa Cruz Biotechnology
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TMEFF1 shRNA (h) Lentiviral Particles - sc-45762-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21462 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21462 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07822 from Sigma-Aldrich
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TMEFF1 siRNA (Human) - CRH5644 from Cohesion Biosciences
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shRNA set against Human TMEFF1 (NM_003692.4) - SHH428676 from Creative biogene
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TMEFF1 shRNA Plasmid (Human) - CHH5644 from Cohesion Biosciences
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TMEFF1 miRNA 3'UTR clone - MiUTR3H-05952 from Creative biogene
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