Gene Symbol | TTPA |
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Entrez Gene | 7274 |
Alt Symbol | ATTP, AVED, TTP1, alphaTTP |
Species | Human |
Gene Type | protein-coding |
Description | tocopherol (alpha) transfer protein |
Other Description | alpha-TTP|alpha-tocopherol transfer protein|tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) |
Swissprots | P49638 Q71V64 |
Accessions | EAW86863 P49638 BC041784 BC058000 AAH58000 D49488 BAA08449 HQ447611 ADQ32097 U21938 AAA64309 XM_006716468 XP_006716531 NM_000370 NP_000361 |
Function | Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity). {ECO:0000250, ECO:0000269|PubMed:7887897}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7887897}. |
TTP-α CRISPR/Cas9 KO Plasmid (h) - sc-411045 from Santa Cruz Biotechnology
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TTP-α HDR Plasmid (h) - sc-411045-HDR from Santa Cruz Biotechnology
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TTP-α Double Nickase Plasmid (h) - sc-411045-NIC from Santa Cruz Biotechnology
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TTP-α Double Nickase Plasmid (h2) - sc-411045-NIC-2 from Santa Cruz Biotechnology
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TTP-α CRISPR Activation Plasmid (h) - sc-411045-ACT from Santa Cruz Biotechnology
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TTP-α CRISPR Activation Plasmid (h2) - sc-411045-ACT-2 from Santa Cruz Biotechnology
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TTP-α Lentiviral Activation Particles (h) - sc-411045-LAC from Santa Cruz Biotechnology
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TTP-α Lentiviral Activation Particles (h2) - sc-411045-LAC-2 from Santa Cruz Biotechnology
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TTP-α siRNA (h) - sc-61734 from Santa Cruz Biotechnology
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TTP-α shRNA Plasmid (h) - sc-61734-SH from Santa Cruz Biotechnology
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TTP-α shRNA (h) Lentiviral Particles - sc-61734-V from Santa Cruz Biotechnology
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Alpha-TTP RNAi - H00007274-R01 from Novus Biologicals
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MISSION® esiRNA - EHU053581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22209 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22209 from Sigma-Aldrich
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TTPA siRNA (Human) - CRH4972 from Cohesion Biosciences
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TTPA - MBS8210866 from MyBioSource
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shRNA set against Human TTPA (NM_000370.3) - SHH437488 from Creative biogene
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Human TTPA siRNA - orb265474 from Biorbyt
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TTPA shRNA Plasmid (Human) - CHH4972 from Cohesion Biosciences
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TTPA miRNA 3'UTR clone - MiUTR4H-TG12713 from Creative biogene
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