Gene Symbol | SLC27A6 |
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Entrez Gene | 28965 |
Alt Symbol | ACSVL2, FACVL2, FATP6, VLCS-H1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 27 (fatty acid transporter), member 6 |
Other Description | FATP-6|VLCSH1|fatty acid transport protein 6|fatty-acid-Coenzyme A ligase, very long-chain 2|hVLCS-H1|long-chain fatty acid transport protein 6|solute carrier family 27 member 6|very long-chain acyl-CoA synthetase homolog 1 |
Swissprots | Q86YF6 Q9Y2P4 Q6IAM5 Q7Z6E6 |
Accessions | EAW62387 Q9Y2P4 AA614135 AF064254 AAD29443 AK313456 BAG36243 AL833117 BC041945 AAH41945 BX537383 CAD97625 CR457129 CAG33410 XM_005271967 XP_005272024 XM_005271968 XP_005272025 XM_005271969 XP_005272026 XM_005271970 XP_005272027 XM_011543348 XP_011541650 NM_001017372 NP_001017372 NM_014031 NP_054750 |
Function | Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. {ECO:0000269|PubMed:12556534}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}. |
Tissue Specificity | Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. {ECO:0000269|PubMed:12556534}. |
Top Pathways | PPAR signaling pathway |
ACSVL2 CRISPR/Cas9 KO Plasmid (h) - sc-412006 from Santa Cruz Biotechnology
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ACSVL2 HDR Plasmid (h) - sc-412006-HDR from Santa Cruz Biotechnology
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ACSVL2 Double Nickase Plasmid (h) - sc-412006-NIC from Santa Cruz Biotechnology
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ACSVL2 Double Nickase Plasmid (h2) - sc-412006-NIC-2 from Santa Cruz Biotechnology
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ACSVL2 CRISPR Activation Plasmid (h) - sc-412006-ACT from Santa Cruz Biotechnology
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ACSVL2 CRISPR Activation Plasmid (h2) - sc-412006-ACT-2 from Santa Cruz Biotechnology
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ACSVL2 Lentiviral Activation Particles (h) - sc-412006-LAC from Santa Cruz Biotechnology
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ACSVL2 Lentiviral Activation Particles (h2) - sc-412006-LAC-2 from Santa Cruz Biotechnology
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ACSVL2 siRNA (h) - sc-91716 from Santa Cruz Biotechnology
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ACSVL2 shRNA Plasmid (h) - sc-91716-SH from Santa Cruz Biotechnology
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ACSVL2 shRNA (h) Lentiviral Particles - sc-91716-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU080191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19536 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19536 from Sigma-Aldrich
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SLC27A6 siRNA (Human) - CRH9132 from Cohesion Biosciences
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SLC27A6 - MBS8215022 from MyBioSource
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shRNA set against Human SLC27A6 (NM_014031.3) - SHH410100 from Creative biogene
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shRNA set against Human SLC27A6(NM_001017372.1) - SHL004924 from Creative biogene
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SLC27A6 shRNA Plasmid (Human) - CHH9132 from Cohesion Biosciences
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SLC27A6 miRNA 3'UTR clone - MiUTR1H-09505 from Creative biogene
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SLC27A6 miRNA 3'UTR clone - MiUTR3H-06632 from Creative biogene
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