Gene Symbol | ATP6V0B |
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Entrez Gene | 533 |
Alt Symbol | ATP6F, HATPL, VMA16 |
Species | Human |
Gene Type | protein-coding |
Description | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b |
Other Description | ATPase, H+ transporting, lysosomal, 21-KD, V0 subunit C-prime, prime|ATPase, H+ transporting, lysosomal, subunit F|H(+)-transporting two-sector ATPase, subunit F|V-ATPase 21 kDa proteolipid subunit|V-ATPase subunit c''|V-type proton ATPase 21 kDa proteolipid subunit|vacuolar ATP synthase 21 kDa proteolipid subunit|vacuolar proton pump 21 kDa proteolipid subunit |
Swissprots | Q6IB32 Q99437 D3DPY5 |
Accessions | BAC02927 EAX07066 EAX07067 EAX07068 EAX07069 Q99437 AI439545 BC000423 AAH00423 BC005876 AAH05876 BC042664 BC053601 BG475609 BG831921 BI770034 BP250477 BT007151 AAP35815 CR456972 CAG33253 D89052 BAA13753 L05089 AAC15853 NM_001039457 NP_001034546 NM_001294333 NP_001281262 NM_004047 NP_004038 |
Function | Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. |
Subcellular Location | Vacuole membrane; Multi-pass membrane protein. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Tuberculosis, Synaptic vesicle cycle, Rheumatoid arthritis, Phagosome, Lysosome |
ATP6F CRISPR/Cas9 KO Plasmid (h) - sc-406611 from Santa Cruz Biotechnology
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ATP6F HDR Plasmid (h) - sc-406611-HDR from Santa Cruz Biotechnology
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ATP6F Double Nickase Plasmid (h) - sc-406611-NIC from Santa Cruz Biotechnology
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ATP6F Double Nickase Plasmid (h2) - sc-406611-NIC-2 from Santa Cruz Biotechnology
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ATP6F CRISPR Activation Plasmid (h) - sc-406611-ACT from Santa Cruz Biotechnology
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ATP6F CRISPR Activation Plasmid (h2) - sc-406611-ACT-2 from Santa Cruz Biotechnology
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ATP6F Lentiviral Activation Particles (h) - sc-406611-LAC from Santa Cruz Biotechnology
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ATP6F Lentiviral Activation Particles (h2) - sc-406611-LAC-2 from Santa Cruz Biotechnology
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ATP6F siRNA (h) - sc-78935 from Santa Cruz Biotechnology
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ATP6F shRNA Plasmid (h) - sc-78935-SH from Santa Cruz Biotechnology
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ATP6F shRNA (h) Lentiviral Particles - sc-78935-V from Santa Cruz Biotechnology
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ATP6V0B RNAi - H00000533-R02 from Novus Biologicals
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MISSION® esiRNA - EHU142591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3720 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3720 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01798 from Sigma-Aldrich
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ATP6V0B siRNA (Human) - CRH0368 from Cohesion Biosciences
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ATP6V0B - MBS827537 from MyBioSource
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ATP6F CRISPR/Cas9 KO Plasmid (h2) - sc-406611-KO-2 from Santa Cruz Biotechnology
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ATP6F HDR Plasmid (h2) - sc-406611-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ATP6V0B (NM_004047.3) - SHH243014 from Creative biogene
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shRNA set against Human ATP6V0B(NM_001039457.1) - SHG083359 from Creative biogene
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shRNA set against Human ATP6V0B(NM_004047.3) - SHG083431 from Creative biogene
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ATP6V0B shRNA Plasmid (Human) - CHH0368 from Cohesion Biosciences
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ATP6V0B miRNA 3'UTR clone - MiUTR1H-00709 from Creative biogene
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