| Gene Symbol |
MAPRE1
|
| Entrez Gene |
22919
|
| Alt Symbol |
EB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein, RP/EB family, member 1
|
| Other Description |
APC-binding protein EB1|adenomatous polyposis coli-binding protein EB1|end-binding protein 1|microtubule-associated protein RP/EB family member 1
|
| Swissprots |
E1P5M8 B2R6I7 Q15691 Q3KQS8
|
| Accessions |
EAW76348 EAW76349 Q15691 AK297273 BAG59745 AK310817 AK312590 BAG35484 BC040410 BC106068 AAI06069 BC109281 AAI09282 BC128442 AAI28443 BJ992159 BM983860 EU832776 ACE87787 GQ129296 ACT64430 U24166 AAC09471 XM_011528696 XP_011526998 NM_012325 NP_036457
|
| Function |
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:10644998}.
|
![Western Blot: MAPRE1 Overexpression Lysate (Adult Normal) [NBL1-12891] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MAPRE1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3952_MAPRE1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12891-img0002.jpg)