Gene Symbol | CRB2 |
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Entrez Gene | 286204 |
Alt Symbol | FSGS9, VMCKD |
Species | Human |
Gene Type | protein-coding |
Description | crumbs family member 2 |
Other Description | crumbs homolog 2|crumbs-like protein 2|protein crumbs homolog 2 |
Swissprots | Q5JS43 Q0QD46 Q6ZTA9 Q5JS41 Q6ZWI6 Q5IJ48 A2A3N4 |
Accessions | EAW87567 EAW87568 Q5IJ48 AK095783 BAC04626 AK123000 AK124819 AK126775 BAC86684 AY720432 AAU14134 CX871675 DA240339 DQ426866 ABD90532 XM_005251934 XP_005251991 XM_011518556 XP_011516858 XM_011518557 XP_011516859 XM_011518558 XP_011516860 NM_173689 NP_775960 NR_104603 |
Function | May play a role in polarized cells morphogenesis. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in retina, fetal eye and brain. Also expressed in kidney, ARPE-19 and RPE/choroid cell lines, and at low levels in lung, placenta, and heart. {ECO:0000269|PubMed:15851977}. |
Top Pathways | Hippo signaling pathway |
CRB2 CRISPR/Cas9 KO Plasmid (h) - sc-415457 from Santa Cruz Biotechnology
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CRB2 HDR Plasmid (h) - sc-415457-HDR from Santa Cruz Biotechnology
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CRB2 Double Nickase Plasmid (h) - sc-415457-NIC from Santa Cruz Biotechnology
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CRB2 Double Nickase Plasmid (h2) - sc-415457-NIC-2 from Santa Cruz Biotechnology
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CRB2 CRISPR Activation Plasmid (h) - sc-415457-ACT from Santa Cruz Biotechnology
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CRB2 CRISPR Activation Plasmid (h2) - sc-415457-ACT-2 from Santa Cruz Biotechnology
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CRB2 Lentiviral Activation Particles (h) - sc-415457-LAC from Santa Cruz Biotechnology
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CRB2 Lentiviral Activation Particles (h2) - sc-415457-LAC-2 from Santa Cruz Biotechnology
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CRB2 siRNA (h) - sc-92615 from Santa Cruz Biotechnology
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CRB2 shRNA Plasmid (h) - sc-92615-SH from Santa Cruz Biotechnology
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CRB2 shRNA (h) Lentiviral Particles - sc-92615-V from Santa Cruz Biotechnology
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CRB2 RNAi - H00286204-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN6546 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6546 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09906 from Sigma-Aldrich
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CRB2 siRNA (Human) - CRJ7157 from Cohesion Biosciences
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CRB2 - MBS829222 from MyBioSource
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shRNA set against Human CRB2 (NM_173689.5) - SHH269213 from Creative biogene
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Human CRB2 siRNA - orb277658 from Biorbyt
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CRB2 shRNA Plasmid (Human) - CHJ7157 from Cohesion Biosciences
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CRB2 miRNA 3'UTR clone - MiUTR1H-02407 from Creative biogene
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