| Gene Symbol |
PDS5A
|
| Entrez Gene |
23244
|
| Alt Symbol |
PIG54, SCC-112, SCC112
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PDS5 cohesin associated factor A
|
| Other Description |
PDS5, regulator of cohesion maintenance, homolog A|cell proliferation-inducing gene 54 protein|sister chromatid cohesion protein 112|sister chromatid cohesion protein PDS5 homolog A
|
| Swissprots |
Q9Y4D4 Q8N7J4 Q68DF7 Q8NG14 Q29RF7 Q2TTR5
|
| Accessions |
CDM63448 EAW92952 EAW92953 EAW92954 EAW92955 Q29RF7 AB014548 BAA31623 AB621803 BAK64139 AF294791 AAM82347 AK001828 AK021757 BAG51044 AK023592 AK098331 BAC05286 AK124569 AY550968 AAT52214 BC009650 AAH09650 BC041361 AAH41361 BC114218 AAI14219 BC126225 AAI26226 BC144088 CA412233 CR749425 CAH18263 EU832459 ACE87631 EU832474 ACE87646 EU832541 ACE86943 EU832553 ACE86955 HQ257985 ADR82739 XM_011513672 XP_011511974 XM_011513673 XP_011511975 XM_011513674 XP_011511976 NM_001100399 NP_001093869 NM_001100400 NP_001093870 NM_015200
|
| Function |
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:15019998}. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. {ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:15019998}.
|
| Tissue Specificity |
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney. {ECO:0000269|PubMed:15019998}.
|
